SYRE (Spyre Therapeutics) Institutional Ownership: 95.51% (As of Aug. 05, 2026)

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SYRE Spyre Therapeutics Inc SYRE
26 GF Score
Price $105.00
! 4 Warning Signs
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What is Spyre Therapeutics Institutional Ownership?

Spyre Therapeutics SYRE +10.54% 26 Institutional Ownership is 95.51% as of Aug. 05, 2026. GuruFocus rates SYRE with a GF Score™ of 26/100. The stock has 4 warning signs investors should review.

Institutional ownership is the percentage of shares that are owned by institutions out of the total shares outstanding. As of today, Spyre Therapeutics's institutional ownership is 95.51%.

Insider Ownership is the percentage of shares that are owned by company insiders relative to the total shares outstanding. As of today, Spyre Therapeutics's Insider Ownership is 2.59%.

Float Percentage Of Total Shares Outstanding is the percentage of float shares relative to the total shares outstanding. As of today, Spyre Therapeutics's Float Percentage Of Total Shares Outstanding is 93.42%.

Spyre Therapeutics Institutional Ownership Historical Data

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The historical data trend for Spyre Therapeutics's Institutional Ownership can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Spyre Therapeutics Institutional Ownership Chart

Spyre Therapeutics Historical Data

The historical data trend for Spyre Therapeutics can be seen below:

2025-10-31 2025-11-30 2025-12-31 2026-01-31 2026-02-28 2026-03-31 2026-04-30 2026-05-31 2026-06-30 2026-07-31
Institutional Ownership 46.45 47.25 50.81 50.99 51.51 50.95 49.96 51.08 59.15 59.32
SYRE
26GF Score
Spyre Therapeutics Inc SYRE
Institutional Ownership is just one metric. See GF Score™, valuation, warning signs, and more.
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Spyre Therapeutics Institutional Ownership Calculation

The percentage of shares that are owned by institutions out of the total shares outstanding.

What does a Institutional Ownership of 95.51% mean?
Spyre Therapeutics (SYRE) has a Institutional Ownership of 95.51% as of Aug. 05, 2026. Institutional ownership equals the percent of shares owned by financial institutions relative to total shares. View historical data on Spyre Therapeutics and its competitors.
Is Spyre Therapeutics' Institutional Ownership too high?
Spyre Therapeutics' current Institutional Ownership is 95.51%. Overall, Spyre Therapeutics has a GF Score™ of 26/100, reflecting its overall financial health beyond just this single metric.
How does Spyre Therapeutics' Institutional Ownership compare to CRNX and PTGX?
Spyre Therapeutics' Institutional Ownership of 95.51% can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Institutional Ownership for a Biotechnology company?
A good Institutional Ownership depends on the Biotechnology industry context. However, Institutional Ownership should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Institutional Ownership mean?
A high Institutional Ownership can signal that a stock is expensive relative to its fundamentals. Institutional ownership equals the percent of shares owned by financial institutions relative to total shares. View historical data on Spyre Therapeutics and its competitors. Spyre Therapeutics's current Institutional Ownership is 95.51%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Spyre Therapeutics stock overvalued right now?
Spyre Therapeutics (SYRE) has a current Institutional Ownership of 95.51%. The current Institutional Ownership is 95.51%. Spyre Therapeutics' overall GF Score™ is 26/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Institutional Ownership calculated?
Institutional Ownership is calculated from a company's financial statements. For Spyre Therapeutics (SYRE), the current Institutional Ownership is 95.51% as of Aug. 05, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Spyre Therapeutics Business Description

Other Exchanges 3920:Germany
Address 221 Crescent Street, Suite 105, Building 23, Waltham, MA, USA, 02453
Spyre Therapeutics Inc is a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease (IBD) and rheumatic diseases. Spyre's pipeline includes extended half-life antibodies targeting ?4?7, TL1A, and IL-23 in development as monotherapies and pair-wise combinations. It has a single reportable segment, which is the development of biopharmaceutical products for the treatment of patients with IBD and other immune-mediated disease.
26GF Score

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Institutional Ownership is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$105.00
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