SYRE (Spyre Therapeutics) 1-Year Sharpe Ratio: 3.25 (As of Aug. 05, 2026)

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SYRE Spyre Therapeutics Inc SYRE
26 GF Score
Price $102.01
! 4 Warning Signs
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What is Spyre Therapeutics 1-Year Sharpe Ratio?

Spyre Therapeutics SYRE -2.85% 26 1-Year Sharpe Ratio is 3.25 as of Aug. 05, 2026. GuruFocus rates SYRE with a GF Score™ of 26/100. The stock has 4 warning signs investors should review.

The 1-Year Sharpe Ratio measures the additional return that an investor receives per unit of increase in risk over the past year. As of today (2026-08-05), Spyre Therapeutics's 1-Year Sharpe Ratio is 3.25.

Spyre Therapeutics  (NAS:SYRE) 1-Year Sharpe Ratio Explanation

The 1-Year Sharpe Ratio inidicates the risk-adjusted return of an investment over the past year. It is calculated as the annualized result of the average monthly excess return divided by its standard deviation over the past year. The monthly excess return is the monthly investment return minus the monthly risk-free rate (typically the 10-year Treasury Constant Maturity Rate). If the risk-free rate for a specific region is not available, U.S. data is used by default.

The greater a portfolio's Sharpe Ratio, the better its risk-adjusted performance. A negative Sharpe Ratio means the risk-free rate is greater than the portfolio’s historical or projected return, or else the portfolio's return is expected to be negative.

Spyre Therapeutics 1-Year Sharpe Ratio Related Terms

SYRE vs CRNX, PTGX, PRAX: 1-Year Sharpe Ratio Comparison

For the Biotechnology subindustry, Spyre Therapeutics's 1-Year Sharpe Ratio, along with its competitors' market caps and 1-Year Sharpe Ratio data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.

Spyre Therapeutics 1-Year Sharpe Ratio vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Spyre Therapeutics's 1-Year Sharpe Ratio distribution charts can be found below:

* The bar in red indicates where Spyre Therapeutics's 1-Year Sharpe Ratio falls into.


SYRE
26GF Score
Spyre Therapeutics Inc SYRE
1-Year Sharpe Ratio is just one metric. See GF Score™, valuation, warning signs, and more.
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Spyre Therapeutics 1-Year Sharpe Ratio Calculation

The 1-Year Sharpe Ratio measures the performance of an investment such as a stock or portfolio compared to a risk-free asset. A stock / portfolio's 1-Year Sharpe Ratio can be calculated by dividing the difference between the one-year returns of the investment and the risk-free rate, by the standard deviation of the investment returns over one year.

Frequently Asked Questions Learn more about 1-Year Sharpe Ratio →
What does a 1-Year Sharpe Ratio of 3.25 mean?
Spyre Therapeutics (SYRE) has a 1-Year Sharpe Ratio of 3.25 as of Aug. 05, 2026. 1-Year Sharpe Ratio measures the additional return that an investor receives per unit of increase in risk. View historical data for Spyre Therapeutics and its competitors.
Is Spyre Therapeutics' 1-Year Sharpe Ratio too high?
Spyre Therapeutics' current 1-Year Sharpe Ratio is 3.25. Overall, Spyre Therapeutics has a GF Score™ of 26/100, reflecting its overall financial health beyond just this single metric.
How does Spyre Therapeutics' 1-Year Sharpe Ratio compare to CRNX and PTGX?
Spyre Therapeutics' 1-Year Sharpe Ratio of 3.25 can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good 1-Year Sharpe Ratio for a Biotechnology company?
A good 1-Year Sharpe Ratio depends on the Biotechnology industry context. However, 1-Year Sharpe Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high 1-Year Sharpe Ratio mean?
A high 1-Year Sharpe Ratio can signal that a stock is expensive relative to its fundamentals. 1-Year Sharpe Ratio measures the additional return that an investor receives per unit of increase in risk. View historical data for Spyre Therapeutics and its competitors. Spyre Therapeutics's current 1-Year Sharpe Ratio is 3.25. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Spyre Therapeutics stock overvalued right now?
Spyre Therapeutics (SYRE) has a current 1-Year Sharpe Ratio of 3.25. The current 1-Year Sharpe Ratio is 3.25. Spyre Therapeutics' overall GF Score™ is 26/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is 1-Year Sharpe Ratio calculated?
1-Year Sharpe Ratio is calculated from a company's financial statements. For Spyre Therapeutics (SYRE), the current 1-Year Sharpe Ratio is 3.25 as of Aug. 05, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Spyre Therapeutics Business Description

Other Exchanges 3920:Germany
Address 221 Crescent Street, Suite 105, Building 23, Waltham, MA, USA, 02453
Spyre Therapeutics Inc is a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease (IBD) and rheumatic diseases. Spyre's pipeline includes extended half-life antibodies targeting ?4?7, TL1A, and IL-23 in development as monotherapies and pair-wise combinations. It has a single reportable segment, which is the development of biopharmaceutical products for the treatment of patients with IBD and other immune-mediated disease.
26GF Score

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1-Year Sharpe Ratio is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$102.01
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