SYRE (Spyre Therapeutics) 5-Year EBITDA Growth Rate: 39.10% (As of Jun. 2026)

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SYRE Spyre Therapeutics Inc SYRE
26 GF Score
Price $87.62
! 3 Warning Signs
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What is Spyre Therapeutics 5-Year EBITDA Growth Rate?

Spyre Therapeutics SYRE -3.06% 26 5-Year EBITDA Growth Rate is 39.10% as of Jun. 2026. GuruFocus rates SYRE with a GF Score™ of 26/100. The stock has 3 warning signs investors should review.

Spyre Therapeutics's EBITDA per Share for the three months ended in Jun. 2026 was $-0.96.

During the past 3 years, the average EBITDA Per Share Growth Rate was 48.10% per year. During the past 5 years, the average EBITDA Per Share Growth Rate was 39.10% per year. During the past 10 years, the average EBITDA Per Share Growth Rate was 20.50% per year. Please click Growth Rate Calculation Example (GuruFocus) to see how GuruFocus calculates Wal-Mart Stores Inc (WMT)'s revenue growth rate. You can apply the same method to get the average EBITDA per share growth rate.

During the past 13 years, the highest 3-Year average EBITDA Per Share Growth Rate of Spyre Therapeutics was 48.10% per year. The lowest was -30.20% per year. And the median was 21.10% per year.

Spyre Therapeutics  (NAS:SYRE) 5-Year EBITDA Growth Rate Explanation

EBITDA per Share is the amount of Earnings Before Interest, Taxes, Depreciation, and Amortization (EBITDA) per outstanding share of the company's stock.

Earnings Before Interest, Taxes, Depreciation, and Amortization (EBITDA) is what the company earns before it expenses interest, taxes, depreciation and amortization.

5-Year EBITDA Growth Rate gives an overview of the company's growth in operating profitability and is an important factor used in calculating Peter Lynch Fair Value.

Spyre Therapeutics 5-Year EBITDA Growth Rate Related Terms

SYRE vs TGTX, IMVT, IBRX: 5-Year EBITDA Growth Rate Comparison

For the Biotechnology subindustry, Spyre Therapeutics's 5-Year EBITDA Growth Rate, along with its competitors' market caps and 5-Year EBITDA Growth Rate data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.

Spyre Therapeutics 5-Year EBITDA Growth Rate vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Spyre Therapeutics's 5-Year EBITDA Growth Rate distribution charts can be found below:

* The bar in red indicates where Spyre Therapeutics's 5-Year EBITDA Growth Rate falls into.


SYRE
26GF Score
Spyre Therapeutics Inc SYRE
5-Year EBITDA Growth Rate is just one metric. See GF Score™, valuation, warning signs, and more.
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Spyre Therapeutics 5-Year EBITDA Growth Rate Calculation

This is the 5-year average growth rate of EBITDA per Share. The growth rate is calculated with least square regression.

Please click Growth Rate Calculation Example (GuruFocus) to see how GuruFocus calculates Wal-Mart Stores Inc (WMT)'s revenue growth rate. You can apply the same method to get the average EBITDA per share growth rate.

What does a 5-Year EBITDA Growth Rate of 39.10% mean?
Spyre Therapeutics (SYRE) has a 5-Year EBITDA Growth Rate of 39.10% as of Jun. 2026. 5-Year EBITDA Growth Rate is the 5-year average growth rate of EBITDA per share. View historical data for Spyre Therapeutics and its competitors.
Is Spyre Therapeutics' 5-Year EBITDA Growth Rate too high?
Spyre Therapeutics' current 5-Year EBITDA Growth Rate is 39.10%. Overall, Spyre Therapeutics has a GF Score™ of 26/100, reflecting its overall financial health beyond just this single metric.
How does Spyre Therapeutics' 5-Year EBITDA Growth Rate compare to TGTX and IMVT?
Spyre Therapeutics' 5-Year EBITDA Growth Rate of 39.10% can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good 5-Year EBITDA Growth Rate for a Biotechnology company?
A good 5-Year EBITDA Growth Rate depends on the Biotechnology industry context. However, 5-Year EBITDA Growth Rate should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high 5-Year EBITDA Growth Rate mean?
A high 5-Year EBITDA Growth Rate can signal that a stock is expensive relative to its fundamentals. 5-Year EBITDA Growth Rate is the 5-year average growth rate of EBITDA per share. View historical data for Spyre Therapeutics and its competitors. Spyre Therapeutics's current 5-Year EBITDA Growth Rate is 39.10%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Spyre Therapeutics stock overvalued right now?
Spyre Therapeutics (SYRE) has a current 5-Year EBITDA Growth Rate of 39.10%. The current 5-Year EBITDA Growth Rate is 39.10%. Spyre Therapeutics' overall GF Score™ is 26/100 with 3 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is 5-Year EBITDA Growth Rate calculated?
5-Year EBITDA Growth Rate is calculated from a company's financial statements. For Spyre Therapeutics (SYRE), the current 5-Year EBITDA Growth Rate is 39.10% as of Jun. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Spyre Therapeutics Business Description

Other Exchanges 3920:Germany
Address 221 Crescent Street, Suite 105, Building 23, Waltham, MA, USA, 02453
Spyre Therapeutics Inc is a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease (IBD) and rheumatic diseases. Spyre's pipeline includes extended half-life antibodies targeting ?4?7, TL1A, and IL-23 in development as monotherapies and pair-wise combinations. It has a single reportable segment, which is the development of biopharmaceutical products for the treatment of patients with IBD and other immune-mediated disease.
26GF Score

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5-Year EBITDA Growth Rate is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$87.62
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