Focused on building reliable datasets, financial models, and research tools for value-minded investors. Committed to turning complex data into practical guidance for value-investing and long-term wealth.
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.
Spyre TherapeuticsSYRE +10.54%26 Return-on-Tangible-Asset is -35.81% as of Mar. 2026. GuruFocus rates SYRE with a GF Score™ of 26/100. The stock has 4 warning signs investors should review. Among 1,416 Biotechnology companies, Spyre Therapeutics ranks better than 55.23% on this metric.
Return-on-Tangible-Asset is calculated as Net Income divided by its average total tangible assets. Total tangible assets equals to Total Assets minus Intangible Assets. Spyre Therapeutics's annualizedNet Income for the quarter that ended in Mar. 2026 was $-276.02 Mil. Spyre Therapeutics's average total tangible assets for the quarter that ended in Mar. 2026 was $770.87 Mil. Therefore, Spyre Therapeutics's annualized Return-on-Tangible-Asset for the quarter that ended in Mar. 2026 was -35.81%.
The historical rank and industry rank for Spyre Therapeutics's Return-on-Tangible-Asset or its related term are showing as below:
SYRE'
s Return-on-Tangible-Asset Range Over the Past 10 Years
Min: -164.06 Med: -57.28 Max: -22.39
Current: -28.44
During the past 13 years, Spyre Therapeutics's highest Return-on-Tangible-Asset was -22.39%. The lowest was -164.06%. And the median was -57.28%.
SYRE's Return-on-Tangible-Asset is ranked better than 55.23% of 1416
companies
in the Biotechnology industry
Industry Median: -35.435
vs SYRE: -28.44
Return-on-Tangible-Asset measures the rate of return on the average total tangible assets (total assets minus intangible assets). Tangible means physical in nature. Intangible Assets are assets that are not physical in nature, and typically "derive their value from legal or intellectual rights." Return-on-Tangible-Asset measures a firm's efficiency at generating profits from its tangible assets. It shows how well a company uses what it has to generate earnings. Return-on-Tangible-Assets can vary drastically across industries. Therefore, Return-on-Tangible-Asset should not be used to compare companies in different industries.
Be Aware
Like ROE and ROA, Return-on-Tangible-Asset is calculated with only 12 months data. Fluctuations in the companys earnings or business cycles can affect the ratio drastically. It is important to look at the ratio from a long term perspective. Return-on-Tangible-Asset can be affected by events such as stock buyback or issuance, and by a companys tax rate and its interest payment. Return-on-Tangible-Asset may not reflect the true earning power of the assets. A more accurate measurement is ROC % (ROC).
Many analysts argue the higher return the better. Buffett states that really high Return-on-Tangible-Asset may indicate vulnerability in the durability of the competitive advantage.
Spyre Therapeutics Return-on-Tangible-Asset Related Terms
Spyre Therapeutics Return-on-Tangible-Asset Historical Data
* Premium members only.
The historical data trend for Spyre Therapeutics's Return-on-Tangible-Asset can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
SYRE vs CRNX, PTGX, PRAX: Return-on-Tangible-Asset Comparison
For the Biotechnology subindustry, Spyre Therapeutics's Return-on-Tangible-Asset, along with its competitors' market caps and Return-on-Tangible-Asset data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Spyre Therapeutics Return-on-Tangible-Asset vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Spyre Therapeutics's Return-on-Tangible-Asset distribution charts can be found below:
* The bar in red indicates where Spyre Therapeutics's Return-on-Tangible-Asset falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
In the calculation of annual Return-on-Tangible-Asset, the net income of the last fiscal year and the average total tangible assets over the fiscal year are used. In calculating the quarterly data,
the Net Income data used here is four times the quarterly (Mar. 2026) net income data.
What does a Return-on-Tangible-Asset of -35.81% mean?
Spyre Therapeutics (SYRE) has a Return-on-Tangible-Asset of -35.81% as of Mar. 2026. Return on tangible assets is the ratio of current-period net income to average two-period tangible assets. View historical data on Spyre Therapeutics and its competitors. According to the industry distribution chart, Spyre Therapeutics ranks #634 out of 1416 companies in the Biotechnology industry, placing it in the top 44.8%.
Is Spyre Therapeutics' Return-on-Tangible-Asset too high?
Spyre Therapeutics' current Return-on-Tangible-Asset is -35.81%. Based on the distribution chart, Spyre Therapeutics ranks #634 out of 1416 companies in the Biotechnology industry, which is above the industry midpoint. Overall, Spyre Therapeutics has a GF Score™ of 26/100, reflecting its overall financial health beyond just this single metric.
How does Spyre Therapeutics' Return-on-Tangible-Asset compare to CRNX and PTGX?
According to the Biotechnology industry distribution chart, Spyre Therapeutics ranks #634 out of 1416 companies for Return-on-Tangible-Asset. This puts Spyre Therapeutics in the upper half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Return-on-Tangible-Asset for a Biotechnology company?
A good Return-on-Tangible-Asset depends on the Biotechnology industry context. However, Return-on-Tangible-Asset should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Return-on-Tangible-Asset mean?
A high Return-on-Tangible-Asset can signal that a stock is expensive relative to its fundamentals. Return on tangible assets is the ratio of current-period net income to average two-period tangible assets. View historical data on Spyre Therapeutics and its competitors. Spyre Therapeutics's current Return-on-Tangible-Asset is -35.81%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Spyre Therapeutics stock overvalued right now?
Spyre Therapeutics (SYRE) has a current Return-on-Tangible-Asset of -35.81%. The current Return-on-Tangible-Asset is -35.81%. Spyre Therapeutics' overall GF Score™ is 26/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Return-on-Tangible-Asset calculated?
Return-on-Tangible-Asset is calculated from a company's financial statements. For Spyre Therapeutics (SYRE), the current Return-on-Tangible-Asset is -35.81% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Spyre Therapeutics Inc is a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease (IBD) and rheumatic diseases. Spyre's pipeline includes extended half-life antibodies targeting ?4?7, TL1A, and IL-23 in development as monotherapies and pair-wise combinations. It has a single reportable segment, which is the development of biopharmaceutical products for the treatment of patients with IBD and other immune-mediated disease.
26GF Score
Get the complete analysis for SYRE
Return-on-Tangible-Asset is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.
Quick Browse
Personalize
Premium Gurus 
Create New Portfolio
SYRE has been successfully added to your 
