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Spyre TherapeuticsSYRE -1.81%26 EV-to-OCF is -39.89 as of Aug. 19, 2026. GuruFocus rates SYRE with a GF Score™ of 26/100. The stock has 4 warning signs investors should review. Among 1,408 Biotechnology companies, Spyre Therapeutics ranks better than 89.84% on this metric.
EV-to-OCF is calculated as enterprise value divided by its cash flow from operations. As of today, Spyre Therapeutics's Enterprise Value is $8,335.15 Mil.
Spyre Therapeutics's Cash Flow from Operations for the trailing twelve months (TTM) ended in Jun. 2026 was $-208.94 Mil. Therefore, Spyre Therapeutics's EV-to-OCF for today is -39.89.
The historical rank and industry rank for Spyre Therapeutics's EV-to-OCF or its related term are showing as below:
SYRE'
s EV-to-OCF Range Over the Past 10 Years
Min: -41.64 Med: -2.56 Max: 2.79
Current: -39.89
During the past 13 years, the highest EV-to-OCF of Spyre Therapeutics was 2.79. The lowest was -41.64. And the median was -2.56.
SYRE's EV-to-OCF is ranked better than 89.84% of 1408
companies
in the Biotechnology industry
Industry Median: -3.66
vs SYRE: -39.89
EV-to-OCF is a valuation multiple that allows analysts and investors to compare stocks, preferably in the same sector or industry. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio (TTM) to determine the fair market value of a company.
EV-to-OCF is a valuation multiple that allows analysts and investors to compare stocks, preferably in the same sector or industry. This important multiple is often used in conjunction with, or as an alternative to, the PE Ratio (TTM) to determine the fair market value of a company.
Spyre Therapeutics's PE Ratio (TTM) for today is calculated as:
Spyre Therapeutics's share price for today is $105.86.
Spyre Therapeutics's Earnings per Share (Diluted) for the trailing twelve months (TTM) ended in Jun. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-2.049.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Enterprise Value is used because it is a more complete measure in reflecting how much an investor pays when buying a company. Cash Flow from Operations is an important financial metric because it represents the cash generated from operating activities at a company's disposal. Companies with a low EV-to-OCF ratio, combined with a strong balance sheet are generally considered as undervalued.
Spyre Therapeutics EV-to-OCF Related Terms
Spyre Therapeutics EV-to-OCF Historical Data
* Premium members only.
The historical data trend for Spyre Therapeutics's EV-to-OCF can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
For the Biotechnology subindustry, Spyre Therapeutics's EV-to-OCF, along with its competitors' market caps and EV-to-OCF data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Spyre Therapeutics EV-to-OCF vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Spyre Therapeutics's EV-to-OCF distribution charts can be found below:
* The bar in red indicates where Spyre Therapeutics's EV-to-OCF falls into.
Spyre Therapeutics's current Enterprise Value is $8,335.15 Mil.
Spyre Therapeutics's Cash Flow from Operations for the trailing twelve months (TTM) ended in Jun. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-208.94 Mil.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Spyre Therapeutics (SYRE) has a EV-to-OCF of -39.89 as of Aug. 19, 2026. According to the industry distribution chart, Spyre Therapeutics ranks #143 out of 1408 companies in the Biotechnology industry, placing it in the top 10.2%.
Is Spyre Therapeutics' EV-to-OCF too high?
Spyre Therapeutics' current EV-to-OCF is -39.89. Based on the distribution chart, Spyre Therapeutics ranks #143 out of 1408 companies in the Biotechnology industry, which is in the top quartile — a strong position relative to peers. Overall, Spyre Therapeutics has a GF Score™ of 26/100, reflecting its overall financial health beyond just this single metric.
How does Spyre Therapeutics' EV-to-OCF compare to CRNX and PTGX?
According to the Biotechnology industry distribution chart, Spyre Therapeutics ranks #143 out of 1408 companies for EV-to-OCF. This places Spyre Therapeutics in the top 10% of its industry — outperforming the majority of peers. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good EV-to-OCF for a Biotechnology company?
A good EV-to-OCF depends on the Biotechnology industry context. However, EV-to-OCF should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high EV-to-OCF mean?
A high EV-to-OCF can signal that a stock is expensive relative to its fundamentals. Spyre Therapeutics's current EV-to-OCF is -39.89. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Spyre Therapeutics stock overvalued right now?
Spyre Therapeutics (SYRE) has a current EV-to-OCF of -39.89. The current EV-to-OCF is -39.89. Spyre Therapeutics' overall GF Score™ is 26/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is EV-to-OCF calculated?
EV-to-OCF is calculated from a company's financial statements. For Spyre Therapeutics (SYRE), the current EV-to-OCF is -39.89 as of Aug. 19, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Spyre Therapeutics Inc is a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease (IBD) and rheumatic diseases. Spyre's pipeline includes extended half-life antibodies targeting ?4?7, TL1A, and IL-23 in development as monotherapies and pair-wise combinations. It has a single reportable segment, which is the development of biopharmaceutical products for the treatment of patients with IBD and other immune-mediated disease.
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