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Upstream BioUPB +1.13%13 3-Year Share Buyback Ratio is -1.80 as of Jun. 2026. GuruFocus rates UPB with a GF Score™ of 13/100. The stock has 3 warning signs investors should review. Among 1,190 Biotechnology companies, Upstream Bio ranks better than 78.91% on this metric.
Shares Outstanding (EOP) are shares that have been authorized, issued, and purchased by investors and are held by them.
3-Year Share Buyback Ratio measures the average annual proportion of a company's outstanding shares repurchased over the past three years. It is calculated as the annualized percentage change in shares outstanding from three years ago to the current year. A positive ratio may indicate share buybacks over the period, while a zero or negative ratio may reflect no repurchases or potential share issuance. Upstream Bio's current 3-Year Share Buyback Ratio was -1.80%.
The historical rank and industry rank for Upstream Bio's 3-Year Share Buyback Ratio or its related term are showing as below:
UPB'
s 3-Year Share Buyback Ratio Range Over the Past 10 Years
Min: -1.8 Med: -1.8 Max: -1.8
Current: -1.8
During the past 4 years, Upstream Bio's highest 3-Year Share Buyback Ratio was -1.80%. The lowest was -1.80%. And the median was -1.80%.
UPB's 3-Year Share Buyback Ratio is ranked better than 78.91% of 1190
companies
in the Biotechnology industry
Industry Median: -11.75
vs UPB: -1.80
Upstream Bio (NAS:UPB) 3-Year Share Buyback Ratio Explanation
A negative number means the company might be issuing new shares. A positive number indicates that the company is buying back shares.
Be Aware
Investors usually like share buybacks. But as pointed by Warren Buffett, only if a company buys back shares at the prices below the stock's intrinsic value, it rewards remaining shareholders. If a company buys its overvalued stocks back, it destroys shareholder value.
Upstream Bio 3-Year Share Buyback Ratio Related Terms
UPB vs RCKT, ABEO, INDP: 3-Year Share Buyback Ratio Comparison
For the Biotechnology subindustry, Upstream Bio's 3-Year Share Buyback Ratio, along with its competitors' market caps and 3-Year Share Buyback Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Upstream Bio 3-Year Share Buyback Ratio vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Upstream Bio's 3-Year Share Buyback Ratio distribution charts can be found below:
* The bar in red indicates where Upstream Bio's 3-Year Share Buyback Ratio falls into.
Upstream Bio 3-Year Share Buyback Ratio Calculation
This is the annualized percentage change in shares outstanding from three years ago to the current year. The annualized percentage change is calculated with expontential compound based on the latest four years of annual data on Shares Outstanding (EOP).
Please click Growth Rate Calculation Example (GuruFocus) to see how GuruFocus calculates Wal-Mart Stores Inc (WMT)'s revenue growth rate. You can apply the same method to get the average dividends per share growth rate.
What does a 3-Year Share Buyback Ratio of -1.80 mean?
Upstream Bio (UPB) has a 3-Year Share Buyback Ratio of -1.80 as of Jun. 2026. The 3-Year Share Buyback Ratio measures the average annual proportion of a company's outstanding shares repurchased over the past three years. It is calculated as the annualized percentage change in shares outstanding from three years ago to the current year. View historical data for Upstream Bio and its competitors. According to the industry distribution chart, Upstream Bio ranks #251 out of 1190 companies in the Biotechnology industry, placing it in the top 21.1%.
Is Upstream Bio's 3-Year Share Buyback Ratio too high?
Upstream Bio's current 3-Year Share Buyback Ratio is -1.80. Based on the distribution chart, Upstream Bio ranks #251 out of 1190 companies in the Biotechnology industry, which is in the top quartile — a strong position relative to peers. Overall, Upstream Bio has a GF Score™ of 13/100, reflecting its overall financial health beyond just this single metric.
How does Upstream Bio's 3-Year Share Buyback Ratio compare to RCKT and ABEO?
According to the Biotechnology industry distribution chart, Upstream Bio ranks #251 out of 1190 companies for 3-Year Share Buyback Ratio. This places Upstream Bio in the top 21% of its industry — outperforming the majority of peers. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good 3-Year Share Buyback Ratio for a Biotechnology company?
A good 3-Year Share Buyback Ratio depends on the Biotechnology industry context. However, 3-Year Share Buyback Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high 3-Year Share Buyback Ratio mean?
A high 3-Year Share Buyback Ratio can signal that a stock is expensive relative to its fundamentals. The 3-Year Share Buyback Ratio measures the average annual proportion of a company's outstanding shares repurchased over the past three years. It is calculated as the annualized percentage change in shares outstanding from three years ago to the current year. View historical data for Upstream Bio and its competitors. Upstream Bio's current 3-Year Share Buyback Ratio is -1.80. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Upstream Bio stock overvalued right now?
Upstream Bio (UPB) has a current 3-Year Share Buyback Ratio of -1.80. The current 3-Year Share Buyback Ratio is -1.80. Upstream Bio's overall GF Score™ is 13/100 with 3 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is 3-Year Share Buyback Ratio calculated?
3-Year Share Buyback Ratio is calculated from a company's financial statements. For Upstream Bio (UPB), the current 3-Year Share Buyback Ratio is -1.80 as of Jun. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Upstream Bio Inc is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. It is developing verekitug, the known antagonist currently in clinical development that targets the receptor for Thymic Stromal Lymphopoietin (TSLP), a cytokine that is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune-mediated diseases. Verekitug has advanced into three separate world-wide, placebo-controlled, randomized Phase 2 clinical trials, two completed in chronic rhinosinusitis with nasal polyps (CRSwNP) and severe asthma, and one ongoing in chronic obstructive pulmonary disease (COPD).
13GF Score
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