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Upstream BioUPB +1.13%13 3-Year EBITDA Growth Rate is -65.30% as of Jun. 2026. GuruFocus rates UPB with a GF Score™ of 13/100. The stock has 3 warning signs investors should review. Among 1,130 Biotechnology companies, Upstream Bio ranks worse than 96.64% on this metric.
During the past 3 years, the average EBITDA Per Share Growth Rate was -65.30% per year.
Please click Growth Rate Calculation Example (GuruFocus) to see how GuruFocus calculates Wal-Mart Stores Inc (WMT)'s revenue growth rate. You can apply the same method to get the average EBITDA per share growth rate.
During the past 4 years, the highest 3-Year average EBITDA Per Share Growth Rate of Upstream Bio was -65.30% per year. The lowest was -65.30% per year. And the median was -65.30% per year.
Upstream Bio (NAS:UPB) 3-Year EBITDA Growth Rate Explanation
EBITDA per Share is the amount of Earnings Before Interest, Taxes, Depreciation, and Amortization (EBITDA) per outstanding share of the company's stock.
Earnings Before Interest, Taxes, Depreciation, and Amortization (EBITDA) is what the company earns before it expenses interest, taxes, depreciation and amortization.
Upstream Bio 3-Year EBITDA Growth Rate Related Terms
UPB vs RCKT, ABEO, INDP: 3-Year EBITDA Growth Rate Comparison
For the Biotechnology subindustry, Upstream Bio's 3-Year EBITDA Growth Rate, along with its competitors' market caps and 3-Year EBITDA Growth Rate data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Upstream Bio 3-Year EBITDA Growth Rate vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Upstream Bio's 3-Year EBITDA Growth Rate distribution charts can be found below:
* The bar in red indicates where Upstream Bio's 3-Year EBITDA Growth Rate falls into.
Upstream Bio 3-Year EBITDA Growth Rate Calculation
This is the 3-year average growth rate of EBITDA per Share. The growth rate is calculated using exponential compounding based on the latest four year annual data.
Please click Growth Rate Calculation Example (GuruFocus) to see how GuruFocus calculates Wal-Mart Stores Inc (WMT)'s revenue growth rate. You can apply the same method to get the average EBITDA per share growth rate.
What does a 3-Year EBITDA Growth Rate of -65.30% mean?
Upstream Bio (UPB) has a 3-Year EBITDA Growth Rate of -65.30% as of Jun. 2026. 3-Year EBITDA Growth Rate is the 3-year average growth rate of EBITDA per share. View historical data for Upstream Bio and its competitors. According to the industry distribution chart, Upstream Bio ranks #1092 out of 1130 companies in the Biotechnology industry, placing it in the top 96.6%.
Is Upstream Bio's 3-Year EBITDA Growth Rate too high?
Upstream Bio's current 3-Year EBITDA Growth Rate is -65.30%. Based on the distribution chart, Upstream Bio ranks #1092 out of 1130 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Upstream Bio has a GF Score™ of 13/100, reflecting its overall financial health beyond just this single metric.
How does Upstream Bio's 3-Year EBITDA Growth Rate compare to RCKT and ABEO?
According to the Biotechnology industry distribution chart, Upstream Bio ranks #1092 out of 1130 companies for 3-Year EBITDA Growth Rate. This places Upstream Bio in the lower half of its industry. The industry median 3-Year EBITDA Growth Rate is 14.85. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good 3-Year EBITDA Growth Rate for a Biotechnology company?
The median 3-Year EBITDA Growth Rate among Biotechnology companies is 14.85, based on 1,130 companies in the industry. Companies in the top quartile (top 25%) have a 3-Year EBITDA Growth Rate significantly above this median, while those in the bottom quartile fall well below. However, 3-Year EBITDA Growth Rate should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high 3-Year EBITDA Growth Rate mean?
A high 3-Year EBITDA Growth Rate can signal that a stock is expensive relative to its fundamentals. 3-Year EBITDA Growth Rate is the 3-year average growth rate of EBITDA per share. View historical data for Upstream Bio and its competitors. For the Biotechnology industry, the median 3-Year EBITDA Growth Rate is 14.85 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Upstream Bio's current 3-Year EBITDA Growth Rate is -65.30%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Upstream Bio stock overvalued right now?
Upstream Bio (UPB) has a current 3-Year EBITDA Growth Rate of -65.30%. The current 3-Year EBITDA Growth Rate is -65.30%. Upstream Bio's overall GF Score™ is 13/100 with 3 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is 3-Year EBITDA Growth Rate calculated?
3-Year EBITDA Growth Rate is calculated from a company's financial statements. For Upstream Bio (UPB), the current 3-Year EBITDA Growth Rate is -65.30% as of Jun. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Upstream Bio Inc is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. It is developing verekitug, the known antagonist currently in clinical development that targets the receptor for Thymic Stromal Lymphopoietin (TSLP), a cytokine that is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune-mediated diseases. Verekitug has advanced into three separate world-wide, placebo-controlled, randomized Phase 2 clinical trials, two completed in chronic rhinosinusitis with nasal polyps (CRSwNP) and severe asthma, and one ongoing in chronic obstructive pulmonary disease (COPD).
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