UPB (Upstream Bio) Retained Earnings: $-374.81 Mil (As of Mar. 2026)

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UPB Upstream Bio Inc UPB
10 GF Score
Price $6.99
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What is Upstream Bio Retained Earnings?

Upstream Bio UPB -3.04% 10 Retained Earnings is $-374.81 Mil as of Mar. 2026. GuruFocus rates UPB with a GF Score™ of 10/100. The stock has 1 warning sign investors should review.

Retained earnings is the accumulated portion of net income that is not distributed to shareholders. Upstream Bio's retained earnings for the quarter that ended in Mar. 2026 was $-374.81 Mil.

Upstream Bio's quarterly retained earnings declined from Sep. 2025 ($-291.76 Mil) to Dec. 2025 ($-334.22 Mil) and declined from Dec. 2025 ($-334.22 Mil) to Mar. 2026 ($-374.81 Mil).

Upstream Bio's annual retained earnings declined from Dec. 2023 ($-127.97 Mil) to Dec. 2024 ($-190.78 Mil) and declined from Dec. 2024 ($-190.78 Mil) to Dec. 2025 ($-334.22 Mil).

Upstream Bio  (NAS:UPB) Retained Earnings Explanation

Historically profitable companies sometimes have negative retained earnings. This is because they have cumulatively paid out more to shareholders than they reported in profits.

For example, in 2011, Microsoft had negative retained earnings. This does not mean the company lost more money than it made over the years. It just means it paid out more money than it earned.

If a company has negative retained earnings, investors should check the 10-year financial results. They should not assume that negative retained earnings prove a company has generally lost money in the past.

Of course, many companies with negative retained earnings have indeed lost money in the past.

Retained Earnings: Warren Buffett's Secret.

One of the most important indicators of durable competitive advantage. Net earnings can be paid out as dividends, used to buy back shares or retained for growth.

If the company loses more than it has accumulated, retained earnings is negative.

If a company isn't adding to its retained earnings, it isn't growing its net worth.

Rate of growth of retained earnings is good indicator whether it's benefiting from a competitive advantage.

Microsoft is negative because it chose to buyback stock and pay dividends.

The more earnings retained, the faster it grows and increases growth rate for future earnings.

Upstream Bio Retained Earnings Historical Data

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The historical data trend for Upstream Bio's Retained Earnings can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Upstream Bio Retained Earnings Chart

Upstream Bio Annual Data
Trend Dec22 Dec23 Dec24 Dec25
Retained Earnings
-107.44 -127.97 -190.78 -334.22

Upstream Bio Quarterly Data
Dec22 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
Retained Earnings Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only -218.05 -258.02 -291.76 -334.22 -374.81
UPB
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Upstream Bio Inc UPB
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Upstream Bio Retained Earnings Calculation

Retained Earnings is the accumulated portion of net income that is not distributed to shareholders. Because the net income was not distributed to shareholders, shareholders' equity is increased by the same amount.

Of course, if a company loses, it is called retained losses, or accumulated losses.

Frequently Asked Questions Learn more about Retained Earnings →
What does a Retained Earnings of $-374.81 Mil mean?
Upstream Bio (UPB) has a Retained Earnings of $-374.81 Mil as of Mar. 2026. Retained earnings is the amount of net income not issued to shareholders. View historical data on Upstream Bio and its competitors.
Is Upstream Bio's Retained Earnings too high?
Upstream Bio's current Retained Earnings is $-374.81 Mil. Overall, Upstream Bio has a GF Score™ of 10/100, reflecting its overall financial health beyond just this single metric.
How does Upstream Bio's Retained Earnings compare to OABI and VNDA?
Upstream Bio's Retained Earnings of $-374.81 Mil can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Retained Earnings for a Biotechnology company?
A good Retained Earnings depends on the Biotechnology industry context. However, Retained Earnings should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Retained Earnings mean?
A high Retained Earnings can signal that a stock is expensive relative to its fundamentals. Retained earnings is the amount of net income not issued to shareholders. View historical data on Upstream Bio and its competitors. Upstream Bio's current Retained Earnings is $-374.81 Mil. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Upstream Bio stock overvalued right now?
Upstream Bio (UPB) has a current Retained Earnings of $-374.81 Mil. The current Retained Earnings is $-374.81 Mil. Upstream Bio's overall GF Score™ is 10/100 with 1 warning sign to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Retained Earnings calculated?
Retained Earnings is calculated from a company's financial statements. For Upstream Bio (UPB), the current Retained Earnings is $-374.81 Mil as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Upstream Bio Business Description

Address 890 Winter Street, Suite 200, Waltham, MA, USA, 02451
Upstream Bio Inc is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. It is developing verekitug, the known antagonist currently in clinical development that targets the receptor for Thymic Stromal Lymphopoietin (TSLP), a cytokine that is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune-mediated diseases. Verekitug has advanced into three separate world-wide, placebo-controlled, randomized Phase 2 clinical trials, two completed in chronic rhinosinusitis with nasal polyps (CRSwNP) and severe asthma, and one ongoing in chronic obstructive pulmonary disease (COPD).
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