UPB (Upstream Bio) Accumulated Depreciation: $-0.44 Mil (As of Jun. 2026)

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UPB Upstream Bio Inc UPB
13 GF Score
Price $6.55
! 3 Warning Signs
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What is Upstream Bio Accumulated Depreciation?

Upstream Bio UPB -1.06% 13 Accumulated Depreciation is $-0.44 Mil as of Jun. 2026. GuruFocus rates UPB with a GF Score™ of 13/100. The stock has 3 warning signs investors should review.

Note: A negative number here means the assets are depreciated. When depricates more, the absolute value gets bigger.

Upstream Bio's quarterly accumulated depreciation increased from Dec. 2025 ($-0.34 Mil) to Mar. 2026 ($-0.39 Mil) and increased from Mar. 2026 ($-0.39 Mil) to Jun. 2026 ($-0.44 Mil).

Upstream Bio's annual accumulated depreciation increased from Dec. 2023 ($-0.07 Mil) to Dec. 2024 ($-0.16 Mil) and increased from Dec. 2024 ($-0.16 Mil) to Dec. 2025 ($-0.34 Mil).

Upstream Bio Accumulated Depreciation Related Terms

Upstream Bio Accumulated Depreciation Historical Data

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The historical data trend for Upstream Bio's Accumulated Depreciation can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Upstream Bio Accumulated Depreciation Chart

Upstream Bio Annual Data
Trend Dec22 Dec23 Dec24 Dec25
Accumulated Depreciation
-0.01 -0.07 -0.16 -0.34

Upstream Bio Quarterly Data
Dec22 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26 Jun26
Accumulated Depreciation Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -0.24 -0.29 -0.34 -0.39 -0.44
UPB
13GF Score
Upstream Bio Inc UPB
Accumulated Depreciation is just one metric. See GF Score™, valuation, warning signs, and more.
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Upstream Bio Accumulated Depreciation Calculation

The cumulative depreciation of an asset up to a single point in its life. Regardless of the method used to calculate it, the depreciation of an asset during a single period is added to the previous period's accumulated depreciation to get the current accumulated depreciation.

What does a Accumulated Depreciation of $-0.44 Mil mean?
Upstream Bio (UPB) has a Accumulated Depreciation of $-0.44 Mil as of Jun. 2026. Accumulated depreciation is a contra-asset item that accounts for the decline in value of long-term assets. View historical data on Upstream Bio and its competitors.
Is Upstream Bio's Accumulated Depreciation too high?
Upstream Bio's current Accumulated Depreciation is $-0.44 Mil. Overall, Upstream Bio has a GF Score™ of 13/100, reflecting its overall financial health beyond just this single metric.
How does Upstream Bio's Accumulated Depreciation compare to IPSC and ZNTL?
Upstream Bio's Accumulated Depreciation of $-0.44 Mil can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Accumulated Depreciation for a Biotechnology company?
A good Accumulated Depreciation depends on the Biotechnology industry context. However, Accumulated Depreciation should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Accumulated Depreciation mean?
A high Accumulated Depreciation can signal that a stock is expensive relative to its fundamentals. Accumulated depreciation is a contra-asset item that accounts for the decline in value of long-term assets. View historical data on Upstream Bio and its competitors. Upstream Bio's current Accumulated Depreciation is $-0.44 Mil. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Upstream Bio stock overvalued right now?
Upstream Bio (UPB) has a current Accumulated Depreciation of $-0.44 Mil. The current Accumulated Depreciation is $-0.44 Mil. Upstream Bio's overall GF Score™ is 13/100 with 3 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Accumulated Depreciation calculated?
Accumulated Depreciation is calculated from a company's financial statements. For Upstream Bio (UPB), the current Accumulated Depreciation is $-0.44 Mil as of Jun. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Upstream Bio Business Description

Address 890 Winter Street, Suite 200, Waltham, MA, USA, 02451
Upstream Bio Inc is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. It is developing verekitug, the known antagonist currently in clinical development that targets the receptor for Thymic Stromal Lymphopoietin (TSLP), a cytokine that is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune-mediated diseases. Verekitug has advanced into three separate world-wide, placebo-controlled, randomized Phase 2 clinical trials, two completed in chronic rhinosinusitis with nasal polyps (CRSwNP) and severe asthma, and one ongoing in chronic obstructive pulmonary disease (COPD).
13GF Score

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$6.55
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