UPB (Upstream Bio) Buyback Yield %: -0.15 (As of Jul. 17, 2026)

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UPB Upstream Bio Inc UPB
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What is Upstream Bio Buyback Yield %?

Upstream Bio UPB -3.04% 10 Buyback Yield % is -0.15 as of Jul. 17, 2026. GuruFocus rates UPB with a GF Score™ of 10/100. The stock has 1 warning sign investors should review. Among 740 Biotechnology companies, Upstream Bio ranks better than 79.46% on this metric.

Buyback yield is the net repurchase of shares outstanding over the market capital of the company. It is a measure of shareholder return.

Upstream Bio's current buyback yield was -0.15%.

Upstream Bio Buyback Yield % Historical Data

* Premium members only.

The historical data trend for Upstream Bio's Buyback Yield % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Upstream Bio Buyback Yield % Chart

Upstream Bio Annual Data
Trend Dec22 Dec23 Dec24 Dec25
Buyback Yield %
0.00 0.00 -30.95 0.00

Upstream Bio Quarterly Data
Dec22 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
Buyback Yield % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only 0.00 0.00 0.00 0.00 -0.12

UPB vs OABI, VNDA, LXEO: Buyback Yield % Comparison

For the Biotechnology subindustry, Upstream Bio's Buyback Yield %, along with its competitors' market caps and Buyback Yield % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.

Upstream Bio Buyback Yield % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Upstream Bio's Buyback Yield % distribution charts can be found below:

* The bar in red indicates where Upstream Bio's Buyback Yield % falls into.


UPB
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Upstream Bio Inc UPB
Buyback Yield % is just one metric. See GF Score™, valuation, warning signs, and more.
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Upstream Bio Buyback Yield % Calculation

Buyback yield is a measure of shareholder return.

Upstream Bio's Buyback Yield for the fiscal year that ended in Dec. 2025 is calculated as

Buyback Yield=Net Issuance of Stock / Market Cap
=- (Repurchase of Stock + Issuance of Stock) / Market Cap
=- (0 + 0) / 1472.5617
=0.00%

Upstream Bio's annualized Buyback Yield for the quarter that ended in Mar. 2026 is calculated as

Buyback Yield=Net Issuance of Stock(TTM) / Market Cap
=- (Repurchase of Stock + Issuance of Stock) (TTM)** / Market Cap
=- (0 + 0.598) / 489.78
=-0.12%

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

** If the quarter corresponds to the year-end period, we will use the annual Repurchase of Stock and Issuance of Stock data .

Frequently Asked Questions Learn more about Buyback Yield % →
What does a Buyback Yield % of -0.15 mean?
Upstream Bio (UPB) has a Buyback Yield % of -0.15 as of Jul. 17, 2026. Share buyback yield equals the net issuance of stock divided by market cap. View historical data on Upstream Bio and its competitors. According to the industry distribution chart, Upstream Bio ranks #152 out of 740 companies in the Biotechnology industry, placing it in the top 20.5%.
Is Upstream Bio's Buyback Yield % too high?
Upstream Bio's current Buyback Yield % is -0.15. Based on the distribution chart, Upstream Bio ranks #152 out of 740 companies in the Biotechnology industry, which is in the top quartile — a strong position relative to peers. Overall, Upstream Bio has a GF Score™ of 10/100, reflecting its overall financial health beyond just this single metric.
How does Upstream Bio's Buyback Yield % compare to OABI and VNDA?
According to the Biotechnology industry distribution chart, Upstream Bio ranks #152 out of 740 companies for Buyback Yield %. This places Upstream Bio in the top 21% of its industry — outperforming the majority of peers. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Buyback Yield % for a Biotechnology company?
A good Buyback Yield % depends on the Biotechnology industry context. However, Buyback Yield % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Buyback Yield % mean?
A high Buyback Yield % can signal that a stock is expensive relative to its fundamentals. Share buyback yield equals the net issuance of stock divided by market cap. View historical data on Upstream Bio and its competitors. Upstream Bio's current Buyback Yield % is -0.15. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Upstream Bio stock overvalued right now?
Upstream Bio (UPB) has a current Buyback Yield % of -0.15. The current Buyback Yield % is -0.15. Upstream Bio's overall GF Score™ is 10/100 with 1 warning sign to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Buyback Yield % calculated?
Buyback Yield % is calculated from a company's financial statements. For Upstream Bio (UPB), the current Buyback Yield % is -0.15 as of Jul. 17, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Upstream Bio Business Description

Address 890 Winter Street, Suite 200, Waltham, MA, USA, 02451
Upstream Bio Inc is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. It is developing verekitug, the known antagonist currently in clinical development that targets the receptor for Thymic Stromal Lymphopoietin (TSLP), a cytokine that is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune-mediated diseases. Verekitug has advanced into three separate world-wide, placebo-controlled, randomized Phase 2 clinical trials, two completed in chronic rhinosinusitis with nasal polyps (CRSwNP) and severe asthma, and one ongoing in chronic obstructive pulmonary disease (COPD).
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