UPB (Upstream Bio) ROE % Adjusted to Book Value: -31.33% (As of Mar. 2026)

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UPB Upstream Bio Inc UPB
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What is Upstream Bio ROE % Adjusted to Book Value?

Upstream Bio UPB -3.04% 10 ROE % Adjusted to Book Value is -31.33% as of Mar. 2026. GuruFocus rates UPB with a GF Score™ of 10/100. The stock has 1 warning sign investors should review.

Upstream Bio's ROE % for the quarter that ended in Mar. 2026 was -50.44%. Upstream Bio's PB Ratio for the quarter that ended in Mar. 2026 was 1.61. Upstream Bio's ROE % Adjusted to Book Value for the quarter that ended in Mar. 2026 was -31.33%.

Upstream Bio ROE % Adjusted to Book Value Related Terms

Upstream Bio ROE % Adjusted to Book Value Historical Data

* Premium members only.

The historical data trend for Upstream Bio's ROE % Adjusted to Book Value can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Upstream Bio ROE % Adjusted to Book Value Chart

Upstream Bio Annual Data
Trend Dec22 Dec23 Dec24 Dec25
ROE % Adjusted to Book Value
0.00 0.00 -19.27 -8.18

Upstream Bio Quarterly Data
Dec22 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
ROE % Adjusted to Book Value Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only -32.20 -25.81 -12.79 -10.92 -31.33

UPB vs OABI, VNDA, LXEO: ROE % Adjusted to Book Value Comparison

For the Biotechnology subindustry, Upstream Bio's ROE % Adjusted to Book Value, along with its competitors' market caps and ROE % Adjusted to Book Value data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.

Upstream Bio ROE % Adjusted to Book Value vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Upstream Bio's ROE % Adjusted to Book Value distribution charts can be found below:

* The bar in red indicates where Upstream Bio's ROE % Adjusted to Book Value falls into.


UPB
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Upstream Bio Inc UPB
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Upstream Bio ROE % Adjusted to Book Value Calculation

Upstream Bio's ROE % Adjusted to Book Value for the fiscal year that ended in Dec. 2025 is calculated as

ROE % Adjusted to Book Value=ROE % / PB Ratio
=-35.43% / 4.33
=-8.18%

Upstream Bio's ROE % Adjusted to Book Value for the quarter that ended in Mar. 2026 is calculated as

ROE % Adjusted to Book Value=ROE % / PB Ratio
=-50.44% / 1.61
=-31.33%

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

What does a ROE % Adjusted to Book Value of -31.33% mean?
Upstream Bio (UPB) has a ROE % Adjusted to Book Value of -31.33% as of Mar. 2026. Return on equity adjusted to book is the ratio of return on equity to price-book ratio. View historical data on Upstream Bio and its competitors.
Is Upstream Bio's ROE % Adjusted to Book Value too high?
Upstream Bio's current ROE % Adjusted to Book Value is -31.33%. Overall, Upstream Bio has a GF Score™ of 10/100, reflecting its overall financial health beyond just this single metric.
How does Upstream Bio's ROE % Adjusted to Book Value compare to OABI and VNDA?
Upstream Bio's ROE % Adjusted to Book Value of -31.33% can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good ROE % Adjusted to Book Value for a Biotechnology company?
A good ROE % Adjusted to Book Value depends on the Biotechnology industry context. However, ROE % Adjusted to Book Value should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high ROE % Adjusted to Book Value mean?
A high ROE % Adjusted to Book Value can signal that a stock is expensive relative to its fundamentals. Return on equity adjusted to book is the ratio of return on equity to price-book ratio. View historical data on Upstream Bio and its competitors. Upstream Bio's current ROE % Adjusted to Book Value is -31.33%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Upstream Bio stock overvalued right now?
Upstream Bio (UPB) has a current ROE % Adjusted to Book Value of -31.33%. The current ROE % Adjusted to Book Value is -31.33%. Upstream Bio's overall GF Score™ is 10/100 with 1 warning sign to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is ROE % Adjusted to Book Value calculated?
ROE % Adjusted to Book Value is calculated from a company's financial statements. For Upstream Bio (UPB), the current ROE % Adjusted to Book Value is -31.33% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Upstream Bio Business Description

Address 890 Winter Street, Suite 200, Waltham, MA, USA, 02451
Upstream Bio Inc is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. It is developing verekitug, the known antagonist currently in clinical development that targets the receptor for Thymic Stromal Lymphopoietin (TSLP), a cytokine that is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune-mediated diseases. Verekitug has advanced into three separate world-wide, placebo-controlled, randomized Phase 2 clinical trials, two completed in chronic rhinosinusitis with nasal polyps (CRSwNP) and severe asthma, and one ongoing in chronic obstructive pulmonary disease (COPD).
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ROE % Adjusted to Book Value is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

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