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UPB (Upstream Bio) Gross Margin % : 0.00% (As of Mar. 2025)


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What is Upstream Bio Gross Margin %?

Gross Margin % is calculated as gross profit divided by its revenue. Upstream Bio's Gross Profit for the three months ended in Mar. 2025 was $0.57 Mil. Upstream Bio's Revenue for the three months ended in Mar. 2025 was $0.57 Mil. Therefore, Upstream Bio's Gross Margin % for the quarter that ended in Mar. 2025 was 0.00%. If there's no value for Cost of Goods Sold, then Gross Margin % is not calculated.


The historical rank and industry rank for Upstream Bio's Gross Margin % or its related term are showing as below:


UPB's Gross Margin % is not ranked *
in the Biotechnology industry.
Industry Median: 60.83
* Ranked among companies with meaningful Gross Margin % only.

Upstream Bio had a gross margin of N/A% for the quarter that ended in Mar. 2025 => No sustainable competitive advantage

The 5-Year average Growth Rate of Gross Margin for Upstream Bio was 0.00% per year.


Upstream Bio Gross Margin % Historical Data

The historical data trend for Upstream Bio's Gross Margin % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

* Premium members only.

Upstream Bio Gross Margin % Chart

Upstream Bio Annual Data
Trend Dec22 Dec23 Dec24
Gross Margin %
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Upstream Bio Quarterly Data
Dec22 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25
Gross Margin % Get a 7-Day Free Trial - - - - -

Competitive Comparison of Upstream Bio's Gross Margin %

For the Biotechnology subindustry, Upstream Bio's Gross Margin %, along with its competitors' market caps and Gross Margin % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Upstream Bio's Gross Margin % Distribution in the Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Upstream Bio's Gross Margin % distribution charts can be found below:

* The bar in red indicates where Upstream Bio's Gross Margin % falls into.


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Upstream Bio Gross Margin % Calculation

Gross Margin is the percentage of Gross Profit out of sales or Revenue. (Note that if there's no value for Cost of Goods Sold, then Gross Margin % is not calculated.)

Upstream Bio's Gross Margin for the fiscal year that ended in Dec. 2024 is calculated as

Gross Margin % (A: Dec. 2024 )=Gross Profit (A: Dec. 2024 ) / Revenue (A: Dec. 2024 )
=2.4 / 2.37
=(Revenue - Cost of Goods Sold) / Revenue
=(2.37 - 0) / 2.37
=N/A %

Upstream Bio's Gross Margin for the quarter that ended in Mar. 2025 is calculated as


Gross Margin % (Q: Mar. 2025 )=Gross Profit (Q: Mar. 2025 ) / Revenue (Q: Mar. 2025 )
=0.6 / 0.566
=(Revenue - Cost of Goods Sold) / Revenue
=(0.566 - 0) / 0.566
=N/A %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

A positive Gross Profit is only the first step for a company to make a net profit. The gross profit needs to be big enough to also cover related labor, equipment, rental, marketing/advertising, research and development and a lot of other costs in selling the products.


Upstream Bio  (NAS:UPB) Gross Margin % Explanation

Warren Buffett believes that firms with excellent long term economics tend to have consistently higher margins.

Durable competitive advantage creates a high Gross Margin % because of the freedom to price in excess of cost. Companies can be categorized by their Gross Margin %

1. Greater than 40% = Durable competitive advantage
2. Less than 40% = Competition eroding margins
3. Less than 20% = no sustainable competitive advantage
Consistency of Gross Margin is key

Upstream Bio had a gross margin of N/A% for the quarter that ended in Mar. 2025 => No sustainable competitive advantage


Be Aware

If a company loses its competitive advantages, usually its gross margin declines well before its sales declines. Watching Gross Margin % and Operating Margin % closely helps avoid value trap situations.


Upstream Bio Gross Margin % Related Terms

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Upstream Bio Business Description

Traded in Other Exchanges
N/A
Address
890 Winter Street, Suite 200, Waltham, MA, USA, 02451
Upstream Bio Inc is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. It is developing verekitug, the known antagonist currently in clinical development that targets the receptor for Thymic Stromal Lymphopoietin (TSLP), a cytokine that is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune-mediated diseases.