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Upstream BioUPB -3.04%10 Return-on-Tangible-Equity is -50.44% as of Mar. 2026. GuruFocus rates UPB with a GF Score™ of 10/100. The stock has 1 warning sign investors should review. Among 1,199 Biotechnology companies, Upstream Bio ranks better than 50.38% on this metric.
Return-on-Tangible-Equity is calculated as Net Income divided by its average total shareholder tangible equity. Total shareholder tangible equity equals to Total Stockholders Equity minus Intangible Assets. Upstream Bio's annualized net income for the quarter that ended in Mar. 2026 was $-162.36 Mil. Upstream Bio's average shareholder tangible equity for the quarter that ended in Mar. 2026 was $321.88 Mil. Therefore, Upstream Bio's annualized Return-on-Tangible-Equity for the quarter that ended in Mar. 2026 was -50.44%.
The historical rank and industry rank for Upstream Bio's Return-on-Tangible-Equity or its related term are showing as below:
UPB'
s Return-on-Tangible-Equity Range Over the Past 10 Years
Min: -41.77 Med: -35.83 Max: -35.43
Current: -41.77
During the past 4 years, Upstream Bio's highest Return-on-Tangible-Equity was -35.43%. The lowest was -41.77%. And the median was -35.83%.
UPB's Return-on-Tangible-Equity is ranked better than 50.38% of 1199
companies
in the Biotechnology industry
Industry Median: -42.4
vs UPB: -41.77
Upstream Bio (NAS:UPB) Return-on-Tangible-Equity Explanation
Return-on-Tangible-Equity measures the rate of return on the ownership interest (shareholder's tangible equity) of the common stock owners. It measures a firm's efficiency at generating profits from every unit of shareholders' tangible equity (shareholders equity minus intangibles). Return-on-Tangible-Equity shows how well a company uses investment funds to generate earnings growth. Return-on-Tangible-Equitys between 15% and 20% are considered desirable.
Be Aware
Net Income is used.
Because a company can increase its Return-on-Tangible-Equity by having more financial leverage, it is important to watch the leverage ratio when investing in high Return-on-Tangible-Equity companies. Like Return-on-Tangible-Asset, Return-on-Tangible-Equity is calculated with only 12 months data. Fluctuations in company's earnings or business cycles can affect the ratio drastically. It is important to look at the ratio from a long term perspective.
Asset light businesses require very few assets to generate very high earnings. Their Return-on-Tangible-Equitys can be extremely high.
Upstream Bio Return-on-Tangible-Equity Related Terms
Upstream Bio Return-on-Tangible-Equity Historical Data
* Premium members only.
The historical data trend for Upstream Bio's Return-on-Tangible-Equity can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
UPB vs OABI, VNDA, LXEO: Return-on-Tangible-Equity Comparison
For the Biotechnology subindustry, Upstream Bio's Return-on-Tangible-Equity, along with its competitors' market caps and Return-on-Tangible-Equity data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Upstream Bio Return-on-Tangible-Equity vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Upstream Bio's Return-on-Tangible-Equity distribution charts can be found below:
* The bar in red indicates where Upstream Bio's Return-on-Tangible-Equity falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
In the calculation of annual Return-on-Tangible-Equity, the net income of the last fiscal year and the average total shareholder tangible equity over the fiscal year are used. In calculating the quarterly data,
the net income data used here is four times the quarterly (Mar. 2026) net income data.
Return-on-Tangible-Equity is displayed in the 10-year financial page.
What does a Return-on-Tangible-Equity of -50.44% mean?
Upstream Bio (UPB) has a Return-on-Tangible-Equity of -50.44% as of Mar. 2026. Return on tangible equity is the ratio of current-period net income to average two-period tangible equity. View historical data on Upstream Bio and its competitors. According to the industry distribution chart, Upstream Bio ranks #595 out of 1199 companies in the Biotechnology industry, placing it in the top 49.6%.
Is Upstream Bio's Return-on-Tangible-Equity too high?
Upstream Bio's current Return-on-Tangible-Equity is -50.44%. Based on the distribution chart, Upstream Bio ranks #595 out of 1199 companies in the Biotechnology industry, which is above the industry midpoint. Overall, Upstream Bio has a GF Score™ of 10/100, reflecting its overall financial health beyond just this single metric.
How does Upstream Bio's Return-on-Tangible-Equity compare to OABI and VNDA?
According to the Biotechnology industry distribution chart, Upstream Bio ranks #595 out of 1199 companies for Return-on-Tangible-Equity. This puts Upstream Bio in the upper half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Return-on-Tangible-Equity for a Biotechnology company?
A good Return-on-Tangible-Equity depends on the Biotechnology industry context. However, Return-on-Tangible-Equity should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Return-on-Tangible-Equity mean?
A high Return-on-Tangible-Equity can signal that a stock is expensive relative to its fundamentals. Return on tangible equity is the ratio of current-period net income to average two-period tangible equity. View historical data on Upstream Bio and its competitors. Upstream Bio's current Return-on-Tangible-Equity is -50.44%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Upstream Bio stock overvalued right now?
Upstream Bio (UPB) has a current Return-on-Tangible-Equity of -50.44%. The current Return-on-Tangible-Equity is -50.44%. Upstream Bio's overall GF Score™ is 10/100 with 1 warning sign to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Return-on-Tangible-Equity calculated?
Return-on-Tangible-Equity is calculated from a company's financial statements. For Upstream Bio (UPB), the current Return-on-Tangible-Equity is -50.44% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Upstream Bio Inc is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. It is developing verekitug, the known antagonist currently in clinical development that targets the receptor for Thymic Stromal Lymphopoietin (TSLP), a cytokine that is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune-mediated diseases. Verekitug has advanced into three separate world-wide, placebo-controlled, randomized Phase 2 clinical trials, two completed in chronic rhinosinusitis with nasal polyps (CRSwNP) and severe asthma, and one ongoing in chronic obstructive pulmonary disease (COPD).
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