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UPB (Upstream Bio) Return-on-Tangible-Equity : -23.83% (As of Mar. 2025)


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What is Upstream Bio Return-on-Tangible-Equity?

Return-on-Tangible-Equity is calculated as Net Income divided by its average total shareholder tangible equity. Total shareholder tangible equity equals to Total Stockholders Equity minus Intangible Assets. Upstream Bio's annualized net income for the quarter that ended in Mar. 2025 was $-109.08 Mil. Upstream Bio's average shareholder tangible equity for the quarter that ended in Mar. 2025 was $457.73 Mil. Therefore, Upstream Bio's annualized Return-on-Tangible-Equity for the quarter that ended in Mar. 2025 was -23.83%.

The historical rank and industry rank for Upstream Bio's Return-on-Tangible-Equity or its related term are showing as below:

UPB' s Return-on-Tangible-Equity Range Over the Past 10 Years
Min: -52.05   Med: -36.23   Max: -36.23
Current: -52.05

During the past 3 years, Upstream Bio's highest Return-on-Tangible-Equity was -36.23%. The lowest was -52.05%. And the median was -36.23%.

UPB's Return-on-Tangible-Equity is ranked worse than
54.93% of 1267 companies
in the Biotechnology industry
Industry Median: -43.12 vs UPB: -52.05

Upstream Bio Return-on-Tangible-Equity Historical Data

The historical data trend for Upstream Bio's Return-on-Tangible-Equity can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

* Premium members only.

Upstream Bio Return-on-Tangible-Equity Chart

Upstream Bio Annual Data
Trend Dec22 Dec23 Dec24
Return-on-Tangible-Equity
- - -36.23

Upstream Bio Quarterly Data
Dec22 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25
Return-on-Tangible-Equity Get a 7-Day Free Trial - - - -54.90 -23.83

Competitive Comparison of Upstream Bio's Return-on-Tangible-Equity

For the Biotechnology subindustry, Upstream Bio's Return-on-Tangible-Equity, along with its competitors' market caps and Return-on-Tangible-Equity data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Upstream Bio's Return-on-Tangible-Equity Distribution in the Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Upstream Bio's Return-on-Tangible-Equity distribution charts can be found below:

* The bar in red indicates where Upstream Bio's Return-on-Tangible-Equity falls into.


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Upstream Bio Return-on-Tangible-Equity Calculation

Upstream Bio's annualized Return-on-Tangible-Equity for the fiscal year that ended in Dec. 2024 is calculated as

Return-on-Tangible-Equity=Net Income/( (Total Tangible Equity+Total Tangible Equity)/ count )
(A: Dec. 2024 )  (A: Dec. 2023 )(A: Dec. 2024 )
=Net Income/( (Total Stockholders Equity - Intangible Assets+Total Stockholders Equity - Intangible Assets )/ count )
(A: Dec. 2024 )  (A: Dec. 2023 )(A: Dec. 2024 )
=-62.806/( (-123.126+469.852 )/ 2 )
=-62.806/173.363
=-36.23 %

Upstream Bio's annualized Return-on-Tangible-Equity for the quarter that ended in Mar. 2025 is calculated as

Return-on-Tangible-Equity=Net Income/( (Total Tangible Equity+Total Tangible Equity)/ count )
(Q: Mar. 2025 )  (Q: Dec. 2024 )(Q: Mar. 2025 )
=Net Income/( (Total Stockholders Equity - Intangible Assets+Total Stockholders Equity - Intangible Assets)/ count )
(Q: Mar. 2025 )  (Q: Dec. 2024 )(Q: Mar. 2025 )
=-109.08/( (469.852+445.61)/ 2 )
=-109.08/457.731
=-23.83 %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

In the calculation of annual Return-on-Tangible-Equity, the net income of the last fiscal year and the average total shareholder tangible equity over the fiscal year are used. In calculating the quarterly data, the net income data used here is four times the quarterly (Mar. 2025) net income data. Return-on-Tangible-Equity is displayed in the 10-year financial page.


Upstream Bio  (NAS:UPB) Return-on-Tangible-Equity Explanation

Return-on-Tangible-Equity measures the rate of return on the ownership interest (shareholder's tangible equity) of the common stock owners. It measures a firm's efficiency at generating profits from every unit of shareholders' tangible equity (shareholders equity minus intangibles). Return-on-Tangible-Equity shows how well a company uses investment funds to generate earnings growth. Return-on-Tangible-Equitys between 15% and 20% are considered desirable.


Be Aware

Net Income is used.

Because a company can increase its Return-on-Tangible-Equity by having more financial leverage, it is important to watch the leverage ratio when investing in high Return-on-Tangible-Equity companies. Like Return-on-Tangible-Asset, Return-on-Tangible-Equity is calculated with only 12 months data. Fluctuations in company's earnings or business cycles can affect the ratio drastically. It is important to look at the ratio from a long term perspective.

Asset light businesses require very few assets to generate very high earnings. Their Return-on-Tangible-Equitys can be extremely high.


Upstream Bio Return-on-Tangible-Equity Related Terms

Thank you for viewing the detailed overview of Upstream Bio's Return-on-Tangible-Equity provided by GuruFocus.com. Please click on the following links to see related term pages.


Upstream Bio Business Description

Traded in Other Exchanges
N/A
Address
890 Winter Street, Suite 200, Waltham, MA, USA, 02451
Upstream Bio Inc is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. It is developing verekitug, the known antagonist currently in clinical development that targets the receptor for Thymic Stromal Lymphopoietin (TSLP), a cytokine that is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune-mediated diseases.