SPRB (Spruce Biosciences) Cash Flow from Operations: $-29.33 Mil (TTM As of Mar. 2026)

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SPRB Spruce Biosciences Inc SPRB
40 GF Score
Price $41.60
GF Value $4.08
Valuation Significantly Overvalued
! 1 Warning Sign
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What is Spruce Biosciences Cash Flow from Operations?

Spruce Biosciences SPRB -1.01% 40 Cash Flow from Operations is $-29.33 Mil as of Mar. 2026. GuruFocus rates SPRB with a GF Score™ of 40/100 and a GF Value™ of $4.08 (Significantly Overvalued). The stock has 1 warning sign investors should review.

Cash flow from operations refers to the cash brought in through a company's normal business operations. It is the cash flow before any investment or financing activities. It is the cash version of net income.

For the three months ended in Mar. 2026, Spruce Biosciences's Net Income From Continuing Operations was $-12.27 Mil. Its Depreciation, Depletion and Amortization was $0.25 Mil. Its Change In Working Capital was $2.43 Mil. Its cash flow from deferred tax was $0.00 Mil. Its Cash from Discontinued Operating Activities was $0.00 Mil. Its Asset Impairment Charge was $0.00 Mil. Its Stock Based Compensation was $0.69 Mil. And its Cash Flow from Others was $0.16 Mil. In all, Spruce Biosciences's Cash Flow from Operations for the three months ended in Mar. 2026 was $-8.73 Mil.


Spruce Biosciences  (NAS:SPRB) Cash Flow from Operations Explanation

For companies reported in indirect method, cash flow from operations contains six items:

1. Net Income From Continuing Operations:
Net Income From Continuing Operations indicates the net income that a firm brings in from ongoing business activities. These activities are expected to continue into the next reporting period. It excludes extraordinary items, income from the cumulative effects of accounting changes, non-recurring items, income from tax loss carry forward, and preferred dividends.

Spruce Biosciences's net income from continuing operations for the three months ended in Mar. 2026 was $-12.27 Mil.

2. Depreciation, Depletion and Amortization:
Depreciation is a present expense that accounts for the past cost of an asset that is now providing benefits.
Depletion and amortization are synonyms for depreciation.
Generally:
The term depreciation is used when discussing man made tangible assets
The term depletion is used when discussing natural tangible assets
The term amortization is used when discussing intangible assets

Spruce Biosciences's depreciation, depletion and amortization for the three months ended in Mar. 2026 was $0.25 Mil.

3. Change In Working Capital:
Working Capital is a measure of a company's short term liquidity or its ability to cover short term liabilities. It is defined as the difference between a company's current assets and current liabilities. Changes in Working Capital is reported in the cash flow statement since it is one of the major ways in which net income can differ from operating cash flow.

Spruce Biosciences's change in working capital for the three months ended in Mar. 2026 was $2.43 Mil. It means Spruce Biosciences's working capital increased by $2.43 Mil from Dec. 2025 to Mar. 2026 .

4. Deferred Tax:
It is the cash flow generated from deferred tax.

Spruce Biosciences's cash flow from deferred tax for the three months ended in Mar. 2026 was $0.00 Mil.

5. Cash from Discontinued Operating Activities:
Net cash from all of the entity's discontinued operating activities.

Spruce Biosciences's cash from discontinued operating Activities for the three months ended in Mar. 2026 was $0.00 Mil.

6. Asset Impairment Charge:
It is the charge against earnings resulting from the aggregate write down of all assets from their carrying value to their fair value.

Spruce Biosciences's asset impairment charge for the three months ended in Mar. 2026 was $0.00 Mil.

7. Stock Based Compensation:
It is a way corporations use stock options to reward employees. It provides executives and employees the opportunity to share in the growth of the company and, if structured properly, can align their interests with the interests of the company's shareholders and investors, without burning the company's cash on hand.

Spruce Biosciences's stock based compensation for the three months ended in Mar. 2026 was $0.69 Mil.

8. Cash Flow from Others:
These are cash differences caused by the change of inventory, accounts payable, accounts receivable etc. For instance, if a company pays its suppliers slower, its cash position will build up faster. If a company receives payments from its customers slower, its account receivables will rise, and its cash position will grow more slowly (or even shrink).

Spruce Biosciences's cash flow from others for the three months ended in Mar. 2026 was $0.16 Mil.


Spruce Biosciences Cash Flow from Operations Related Terms


Spruce Biosciences Cash Flow from Operations Historical Data

* Premium members only.

The historical data trend for Spruce Biosciences's Cash Flow from Operations can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Spruce Biosciences Cash Flow from Operations Chart

Spruce Biosciences Annual Data
Trend Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Cash Flow from Operations
Get a 7-Day Free Trial -35.88 -41.68 -33.28 -55.96 -33.33

Spruce Biosciences Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
Cash Flow from Operations Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -12.73 -8.83 -5.32 -6.46 -8.73
SPRB
40GF Score
Spruce Biosciences Inc SPRB
Cash Flow from Operations is just one metric. See GF Score™, valuation, warning signs, and more.
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Spruce Biosciences Cash Flow from Operations Calculation

Cash flow from operations refers to the cash brought in through a company's normal business operations. It is the cash flow before any investment or financing activities. It is the cash version of net income.

Spruce Biosciences's Cash Flow from Operations for the fiscal year that ended in Dec. 2025 is calculated as:

Spruce Biosciences's Cash Flow from Operations for the quarter that ended in Mar. 2026 is:


Cash Flow from Operations for the trailing twelve months (TTM) ended in Mar. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-29.33 Mil.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

What does a Cash Flow from Operations of $-29.33 Mil mean?
Spruce Biosciences (SPRB) has a Cash Flow from Operations of $-29.33 Mil as of Mar. 2026. Cash Flow from Operations is the amount of cash earned or paid from standard business operations. View historical data for Spruce Biosciences and its competitors.
Is Spruce Biosciences' Cash Flow from Operations too high?
Spruce Biosciences' current Cash Flow from Operations is $-29.33 Mil. Overall, Spruce Biosciences has a GF Score™ of 40/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Spruce Biosciences' Cash Flow from Operations compare to VXRT and VTVT?
Spruce Biosciences' Cash Flow from Operations of $-29.33 Mil can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Cash Flow from Operations for a Biotechnology company?
A good Cash Flow from Operations depends on the Biotechnology industry context. However, Cash Flow from Operations should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Cash Flow from Operations mean?
A high Cash Flow from Operations can signal that a stock is expensive relative to its fundamentals. Cash Flow from Operations is the amount of cash earned or paid from standard business operations. View historical data for Spruce Biosciences and its competitors. Spruce Biosciences's current Cash Flow from Operations is $-29.33 Mil. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Spruce Biosciences stock overvalued right now?
Based on GuruFocus' analysis, Spruce Biosciences (SPRB) is currently considered Significantly Overvalued. The stock's GF Value™ is $4.08, compared to a current price of $41.60 — trading 919.6% above its estimated fair value. The current Cash Flow from Operations is $-29.33 Mil. Spruce Biosciences' overall GF Score™ is 40/100 with 1 warning sign to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Cash Flow from Operations calculated?
Cash Flow from Operations is calculated from a company's financial statements. For Spruce Biosciences (SPRB), the current Cash Flow from Operations is $-29.33 Mil as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Spruce Biosciences (SPRB) Overvalued in 2026?

Based on GuruFocus' analysis, Spruce Biosciences stock appears to be overvalued. The current stock price of $41.60 is trading 919.6% above its estimated GF Value™ of $4.08. GuruFocus considers Spruce Biosciences to be Significantly Overvalued.

Key valuation signals for SPRB:

  • Cash Flow from Operations: $-29.33 Mil
  • GF Value™: $4.08 vs. price of $41.60 (919.6% above fair value)
  • GF Score™: 40/100 with 1 warning sign

No single metric tells the full story. See the SPRB stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Spruce Biosciences Business Description

Address 611 Gateway Boulevard, Suite 740, South San Francisco, CA, USA, 94080
Spruce Biosciences Inc is a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for rare endocrine disorders with unmet medical needs. The company develops biologics and small-molecule product candidates aimed at addressing diseases with unmet medical needs and limited or no approved therapies. Its product candidate, TA-ERT for the treatment of Mucopolysaccharidosis Type IIIB (MPS IIIB), is a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase (rhNAGLU) intended as an enzyme replacement therapy for patients who lack rhNAGLU enzyme activity. TA-ERT is designed to restore rhNAGLU enzyme activity in the central nervous system following intracerebroventricular injection and promote clearance of heparan sulfate in the brain.
40GF Score

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Cash Flow from Operations is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$41.60
Price
$4.08
GF Value