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Spruce BiosciencesSPRB +6.74%40 3-Year Share Buyback Ratio is -63.30 as of Mar. 2026. GuruFocus rates SPRB with a GF Score™ of 40/100 and a GF Value™ of $4.08 (Significantly Overvalued). The stock has 1 warning sign investors should review. Among 1,197 Biotechnology companies, Spruce Biosciences ranks worse than 86.55% on this metric.
Shares Outstanding (EOP) are shares that have been authorized, issued, and purchased by investors and are held by them.
3-Year Share Buyback Ratio measures the average annual proportion of a company's outstanding shares repurchased over the past three years. It is calculated as the annualized percentage change in shares outstanding from three years ago to the current year. A positive ratio may indicate share buybacks over the period, while a zero or negative ratio may reflect no repurchases or potential share issuance. Spruce Biosciences's current 3-Year Share Buyback Ratio was -63.30%.
The historical rank and industry rank for Spruce Biosciences's 3-Year Share Buyback Ratio or its related term are showing as below:
SPRB'
s 3-Year Share Buyback Ratio Range Over the Past 10 Years
Min: -63.3 Med: -20.8 Max: -3.3
Current: -63.3
During the past 8 years, Spruce Biosciences's highest 3-Year Share Buyback Ratio was -3.30%. The lowest was -63.30%. And the median was -20.80%.
SPRB's 3-Year Share Buyback Ratio is ranked worse than 86.55% of 1197
companies
in the Biotechnology industry
Industry Median: -11.6
vs SPRB: -63.30
Spruce Biosciences (NAS:SPRB) 3-Year Share Buyback Ratio Explanation
A negative number means the company might be issuing new shares. A positive number indicates that the company is buying back shares.
Be Aware
Investors usually like share buybacks. But as pointed by Warren Buffett, only if a company buys back shares at the prices below the stock's intrinsic value, it rewards remaining shareholders. If a company buys its overvalued stocks back, it destroys shareholder value.
Spruce Biosciences 3-Year Share Buyback Ratio Related Terms
SPRB vs VXRT, VTVT, ENGN: 3-Year Share Buyback Ratio Comparison
For the Biotechnology subindustry, Spruce Biosciences's 3-Year Share Buyback Ratio, along with its competitors' market caps and 3-Year Share Buyback Ratio data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Spruce Biosciences 3-Year Share Buyback Ratio vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Spruce Biosciences's 3-Year Share Buyback Ratio distribution charts can be found below:
* The bar in red indicates where Spruce Biosciences's 3-Year Share Buyback Ratio falls into.
Spruce Biosciences 3-Year Share Buyback Ratio Calculation
This is the annualized percentage change in shares outstanding from three years ago to the current year. The annualized percentage change is calculated with expontential compound based on the latest four years of annual data on Shares Outstanding (EOP).
Please click Growth Rate Calculation Example (GuruFocus) to see how GuruFocus calculates Wal-Mart Stores Inc (WMT)'s revenue growth rate. You can apply the same method to get the average dividends per share growth rate.
What does a 3-Year Share Buyback Ratio of -63.30 mean?
Spruce Biosciences (SPRB) has a 3-Year Share Buyback Ratio of -63.30 as of Mar. 2026. The 3-Year Share Buyback Ratio measures the average annual proportion of a company's outstanding shares repurchased over the past three years. It is calculated as the annualized percentage change in shares outstanding from three years ago to the current year. View historical data for Spruce Biosciences and its competitors. According to the industry distribution chart, Spruce Biosciences ranks #1036 out of 1197 companies in the Biotechnology industry, placing it in the top 86.5%.
Is Spruce Biosciences' 3-Year Share Buyback Ratio too high?
Spruce Biosciences' current 3-Year Share Buyback Ratio is -63.30. Based on the distribution chart, Spruce Biosciences ranks #1036 out of 1197 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Spruce Biosciences has a GF Score™ of 40/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Spruce Biosciences' 3-Year Share Buyback Ratio compare to VXRT and VTVT?
According to the Biotechnology industry distribution chart, Spruce Biosciences ranks #1036 out of 1197 companies for 3-Year Share Buyback Ratio. This places Spruce Biosciences in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good 3-Year Share Buyback Ratio for a Biotechnology company?
A good 3-Year Share Buyback Ratio depends on the Biotechnology industry context. However, 3-Year Share Buyback Ratio should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high 3-Year Share Buyback Ratio mean?
A high 3-Year Share Buyback Ratio can signal that a stock is expensive relative to its fundamentals. The 3-Year Share Buyback Ratio measures the average annual proportion of a company's outstanding shares repurchased over the past three years. It is calculated as the annualized percentage change in shares outstanding from three years ago to the current year. View historical data for Spruce Biosciences and its competitors. Spruce Biosciences's current 3-Year Share Buyback Ratio is -63.30. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Spruce Biosciences stock overvalued right now?
Based on GuruFocus' analysis, Spruce Biosciences (SPRB) is currently considered Significantly Overvalued. The stock's GF Value™ is $4.08, compared to a current price of $46.26 — trading 1033.8% above its estimated fair value. The current 3-Year Share Buyback Ratio is -63.30. Spruce Biosciences' overall GF Score™ is 40/100 with 1 warning sign to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is 3-Year Share Buyback Ratio calculated?
3-Year Share Buyback Ratio is calculated from a company's financial statements. For Spruce Biosciences (SPRB), the current 3-Year Share Buyback Ratio is -63.30 as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Spruce Biosciences (SPRB) Overvalued in 2026?
Based on GuruFocus' analysis, Spruce Biosciences stock appears to be overvalued.
The current stock price of $46.26 is trading 1033.8% above its estimated GF Value™ of $4.08.
GuruFocus considers Spruce Biosciences to be Significantly Overvalued.
Key valuation signals for SPRB:
3-Year Share Buyback Ratio: -63.30
GF Value™: $4.08 vs. price of $46.26 (1033.8% above fair value)
No single metric tells the full story. See the SPRB stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Spruce Biosciences Inc is a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for rare endocrine disorders with unmet medical needs. The company develops biologics and small-molecule product candidates aimed at addressing diseases with unmet medical needs and limited or no approved therapies. Its product candidate, TA-ERT for the treatment of Mucopolysaccharidosis Type IIIB (MPS IIIB), is a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase (rhNAGLU) intended as an enzyme replacement therapy for patients who lack rhNAGLU enzyme activity. TA-ERT is designed to restore rhNAGLU enzyme activity in the central nervous system following intracerebroventricular injection and promote clearance of heparan sulfate in the brain.
40GF Score
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