SPRB (Spruce Biosciences) FCF Yield %: -20.55 (As of Jun. 24, 2026)


SPRB Spruce Biosciences Inc SPRB
35 GF Score
Price $51.87
GF Value $4.08
Valuation Significantly Overvalued
! 1 Warning Sign
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What is Spruce Biosciences FCF Yield %?

Spruce Biosciences SPRB -1.12% 35 FCF Yield % is -20.55 as of Jun. 24, 2026. GuruFocus rates SPRB with a GF Score™ of 35/100 and a GF Value™ of $4.08 (Significantly Overvalued). The stock has 1 warning sign investors should review. Among 1,417 Biotechnology companies, Spruce Biosciences ranks worse than 66.9% on this metric.

FCF Yield % is calculated as Free Cash Flow divided by Market Capitalization. It is a financial solvency ratio that compares the free cash flow a company is expected to earn against its market value.

As of today, Spruce Biosciences's Trailing 12-Month Free Cash Flow is $-29.34 Mil, and Market Cap is $142.76 Mil. Therefore, Spruce Biosciences's FCF Yield % for today is -20.55%.

The historical rank and industry rank for Spruce Biosciences's FCF Yield % or its related term are showing as below:

SPRB' s FCF Yield % Range Over the Past 10 Years
Min: -1941.24   Med: -133.35   Max: -14.86
Current: -20.55


During the past 8 years, the highest FCF Yield % of Spruce Biosciences was -14.86%. The lowest was -1941.24%. And the median was -133.35%.

SPRB's FCF Yield % is ranked worse than
66.9% of 1417 companies
in the Biotechnology industry
Industry Median: -9.7 vs SPRB: -20.55

Spruce Biosciences's FCF Margin % for the quarter that ended in Mar. 2026 was 0.00%.


Spruce Biosciences FCF Yield % Explanation

Similar to Earnings Yield %, FCF Yield % is financial solvency ratio. A lower ratio suggests a less attractive investment, indicating that investors might not receive substantial returns in proportion to their investment. Conversely, a high free cash flow yield signals that a company generates sufficient cash to comfortably meet its debts, obligations, and dividend payments, making it a promising investment choice.


Spruce Biosciences FCF Yield % Related Terms


Spruce Biosciences FCF Yield % Historical Data

* Premium members only.

The historical data trend for Spruce Biosciences's FCF Yield % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Spruce Biosciences FCF Yield % Chart

Spruce Biosciences Annual Data
Trend Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
FCF Yield %
Get a 7-Day Free Trial -34.36 -160.81 -27.69 -315.57 -27.89

Spruce Biosciences Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
FCF Yield % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -415.59 -1,153.49 -422.00 -21.61 -39.00

SPRB vs HURA, AGEN, CRBP: FCF Yield % Comparison

For the Biotechnology subindustry, Spruce Biosciences's FCF Yield %, along with its competitors' market caps and FCF Yield % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Spruce Biosciences FCF Yield % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Spruce Biosciences's FCF Yield % distribution charts can be found below:

* The bar in red indicates where Spruce Biosciences's FCF Yield % falls into.


SPRB
35GF Score
Spruce Biosciences Inc SPRB
FCF Yield % is just one metric. See GF Score™, valuation, warning signs, and more.
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Spruce Biosciences FCF Yield % Calculation

FCF Yield % is a financial solvency ratio that compares the free cash flow a company is expected to earn against its market value.

Spruce Biosciences's FCF Yield % for the fiscal year that ended in Dec. 2025 is calculated as

FCF Yield %=Free Cash Flow / Market Cap
=-33.327 / 119.51492
=-27.89%

Spruce Biosciences's annualized FCF Yield % for the quarter that ended in Mar. 2026 is calculated as

FCF Yield %=Free Cash Flow * Annualized Factor / Market Cap
=-8.742 * 4 / 89.6602
=-39.00%

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about FCF Yield % →
What does a FCF Yield % of -20.55 mean?
Spruce Biosciences (SPRB) has a FCF Yield % of -20.55 as of Jun. 24, 2026. FCF Yield is calculated as Free Cash Flow divided by Market Capitalization. View historical data on Spruce Biosciences and its competitors. According to the industry distribution chart, Spruce Biosciences ranks #948 out of 1417 companies in the Biotechnology industry, placing it in the top 66.9%.
Is Spruce Biosciences' FCF Yield % too high?
Spruce Biosciences' current FCF Yield % is -20.55. Based on the distribution chart, Spruce Biosciences ranks #948 out of 1417 companies in the Biotechnology industry, which is below the industry midpoint. Overall, Spruce Biosciences has a GF Score™ of 35/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Spruce Biosciences' FCF Yield % compare to HURA and AGEN?
According to the Biotechnology industry distribution chart, Spruce Biosciences ranks #948 out of 1417 companies for FCF Yield %. This places Spruce Biosciences in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good FCF Yield % for a Biotechnology company?
A good FCF Yield % depends on the Biotechnology industry context. However, FCF Yield % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high FCF Yield % mean?
A high FCF Yield % can signal that a stock is expensive relative to its fundamentals. FCF Yield is calculated as Free Cash Flow divided by Market Capitalization. View historical data on Spruce Biosciences and its competitors. Spruce Biosciences's current FCF Yield % is -20.55. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Spruce Biosciences stock overvalued right now?
Based on GuruFocus' analysis, Spruce Biosciences (SPRB) is currently considered Significantly Overvalued. The stock's GF Value™ is $4.08, compared to a current price of $51.87 — trading 1171.3% above its estimated fair value. The current FCF Yield % is -20.55. Spruce Biosciences' overall GF Score™ is 35/100 with 1 warning sign to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is FCF Yield % calculated?
FCF Yield % is calculated from a company's financial statements. For Spruce Biosciences (SPRB), the current FCF Yield % is -20.55 as of Jun. 24, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Spruce Biosciences (SPRB) Overvalued in 2026?

Based on GuruFocus' analysis, Spruce Biosciences stock appears to be overvalued. The current stock price of $51.87 is trading 1171.3% above its estimated GF Value™ of $4.08. GuruFocus considers Spruce Biosciences to be Significantly Overvalued.

Key valuation signals for SPRB:

  • FCF Yield %: -20.55
  • GF Value™: $4.08 vs. price of $51.87 (1171.3% above fair value)
  • GF Score™: 35/100 with 1 warning sign

No single metric tells the full story. See the SPRB stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Spruce Biosciences Business Description

Address 611 Gateway Boulevard, Suite 740, South San Francisco, CA, USA, 94080
Spruce Biosciences Inc is a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for rare endocrine disorders with unmet medical needs. The company develops biologics and small-molecule product candidates aimed at addressing diseases with unmet medical needs and limited or no approved therapies. Its product candidate, TA-ERT for the treatment of Mucopolysaccharidosis Type IIIB (MPS IIIB), is a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase (rhNAGLU) intended as an enzyme replacement therapy for patients who lack rhNAGLU enzyme activity. TA-ERT is designed to restore rhNAGLU enzyme activity in the central nervous system following intracerebroventricular injection and promote clearance of heparan sulfate in the brain.
35GF Score

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FCF Yield % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$51.87
Price
$4.08
GF Value