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Spruce BiosciencesSPRB -1.84%42 Net Cash per Share is $28.03 as of Jun. 2026, which is 2359% above its 10-year median of 1.14. GuruFocus rates SPRB with a GF Score™ of 42/100 and a GF Value™ of $4.08 (Significantly Overvalued). The stock has 1 warning sign investors should review. Among 774 Biotechnology companies, Spruce Biosciences ranks better than 83.2% on this metric.
Spruce Biosciences (NAS:SPRB) Net Cash per Share Explanation
Ben Graham invested in situations where the company's stock price was lower than its net-cash. He assigned some value to the company's other current asset. The value is called Net Current Asset Value (NCAV). One research study, covering the years 1970 through 1983 showed that portfolios picked at the beginning of each year, and held for one year, returned 29.4 percent, on average, over the 13-year period, compared to 11.5 percent for the S&P 500 Index. Other studies of Graham's strategy produced similar results.
You can find companies that are traded below their Net Current Asset Value (NCAV) with our Net-Net screener.
Spruce Biosciences Net Cash per Share Related Terms
Spruce Biosciences Net Cash per Share Historical Data
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The historical data trend for Spruce Biosciences's Net Cash per Share can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
SPRB vs VXRT, VTVT, ENGN: Net Cash per Share Comparison
For the Biotechnology subindustry, Spruce Biosciences's Price-to-Net-Cash, along with its competitors' market caps and Price-to-Net-Cash data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Spruce Biosciences Price-to-Net-Cash vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Spruce Biosciences's Price-to-Net-Cash distribution charts can be found below:
* The bar in red indicates where Spruce Biosciences's Price-to-Net-Cash falls into.
In the calculation of a company's Net Cash per Share, assets other than cash and short term investments are considered to be worth nothing. But the company has to pay its debt and other liabilities in full. This is an extremely conservative way of valuation. Most companies have negative Net Cash per Share. But sometimes a company's price may be lower than its net-cash.
Spruce Biosciences's Net Cash per Share for the fiscal year that ended in Dec. 2025 is calculated as
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Spruce Biosciences (SPRB) has a Net Cash per Share of $28.03 as of Jun. 2026. Net cash per share equals the per-share value of cash and equivalents less total liabilities and minority interest. View historical data on Spruce Biosciences and its competitors. This is 2359% above median its historical median of 1.14. Over the past decade, Spruce Biosciences' Net Cash per Share has ranged from 0.40 to 6.78. According to the industry distribution chart, Spruce Biosciences ranks #130 out of 774 companies in the Biotechnology industry, placing it in the top 16.8%.
Is Spruce Biosciences' Net Cash per Share too high?
Spruce Biosciences' current Net Cash per Share of $28.03 is 2359% above median its 10-year median of 1.14. Over the past 10 years, this metric has ranged from a low of 0.40 to a high of 6.78. The Biotechnology industry median Net Cash per Share is 5.23. Spruce Biosciences' value of $28.03 is 436.5% above this industry median. Based on the distribution chart, Spruce Biosciences ranks #130 out of 774 companies in the Biotechnology industry, which is in the top quartile — a strong position relative to peers. Overall, Spruce Biosciences has a GF Score™ of 42/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Spruce Biosciences' Net Cash per Share compare to VXRT and VTVT?
According to the Biotechnology industry distribution chart, Spruce Biosciences ranks #130 out of 774 companies for Net Cash per Share. This places Spruce Biosciences in the top 17% of its industry — outperforming the majority of peers. The industry median Net Cash per Share is 5.23. Spruce Biosciences' value of $28.03 is 436.5% above this benchmark. Historically, Spruce Biosciences' own Net Cash per Share has ranged from 0.40 to 6.78 over the past decade. While the company's 10-year median is 1.14 vs. the industry median of 5.23, Spruce Biosciences has consistently been above the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Net Cash per Share for a Biotechnology company?
The median Net Cash per Share among Biotechnology companies is 5.23, based on 774 companies in the industry. Companies in the top quartile (top 25%) have a Net Cash per Share significantly above this median, while those in the bottom quartile fall well below. However, Net Cash per Share should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Spruce Biosciences's current Net Cash per Share of $28.03 is 436.5% above the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Net Cash per Share mean?
A high Net Cash per Share can signal that a stock is expensive relative to its fundamentals. Net cash per share equals the per-share value of cash and equivalents less total liabilities and minority interest. View historical data on Spruce Biosciences and its competitors. For the Biotechnology industry, the median Net Cash per Share is 5.23 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Spruce Biosciences's current Net Cash per Share is $28.03, which is 2359% above median its own 10-year median of 1.14. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Spruce Biosciences stock overvalued right now?
Based on GuruFocus' analysis, Spruce Biosciences (SPRB) is currently considered Significantly Overvalued. The stock's GF Value™ is $4.08, compared to a current price of $52.27 — trading 1181.1% above its estimated fair value. The current Net Cash per Share is $28.03, which is 2359% above median its 10-year median of 1.14 and 436.5% above the Biotechnology industry median of 5.23. Spruce Biosciences' overall GF Score™ is 42/100 with 1 warning sign to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Net Cash per Share calculated?
Net Cash per Share is calculated from a company's financial statements. For Spruce Biosciences (SPRB), the current Net Cash per Share is $28.03 as of Jun. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Is Spruce Biosciences (SPRB) Overvalued in 2026?
Based on GuruFocus' analysis, Spruce Biosciences stock appears to be overvalued.
The current stock price of $52.27 is trading 1181.1% above its estimated GF Value™ of $4.08.
GuruFocus considers Spruce Biosciences to be Significantly Overvalued.
Key valuation signals for SPRB:
Net Cash per Share: $28.03 (2359% above median its 10-year median of 1.14)
GF Value™: $4.08 vs. price of $52.27 (1181.1% above fair value)
Industry Position: 436.5% above the Biotechnology median (#130 of 774)
No single metric tells the full story. See the SPRB stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.
Spruce Biosciences Inc is a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for rare endocrine disorders with unmet medical needs. The company develops biologics and small-molecule product candidates aimed at addressing diseases with unmet medical needs and limited or no approved therapies. Its product candidate, TA-ERT for the treatment of Mucopolysaccharidosis Type IIIB (MPS IIIB), is a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase (rhNAGLU) intended as an enzyme replacement therapy for patients who lack rhNAGLU enzyme activity. TA-ERT is designed to restore rhNAGLU enzyme activity in the central nervous system following intracerebroventricular injection and promote clearance of heparan sulfate in the brain.
42GF Score
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