SPRB (Spruce Biosciences) ROC (Joel Greenblatt) %: -7,354.16% (As of Mar. 2026)


SPRB Spruce Biosciences Inc SPRB
40 GF Score
Price $52.51
GF Value $4.08
Valuation Significantly Overvalued
! 1 Warning Sign
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What is Spruce Biosciences ROC (Joel Greenblatt) %?

Spruce Biosciences SPRB -0.07% 40 ROC (Joel Greenblatt) % is -7,354.16% as of Mar. 2026. GuruFocus rates SPRB with a GF Score™ of 40/100 and a GF Value™ of $4.08 (Significantly Overvalued). The stock has 1 warning sign investors should review. Among 1,324 Biotechnology companies, Spruce Biosciences ranks worse than 84.82% on this metric.

Joel Greenblatt defined Return on Capital differently in his book The Little Book That Still Beats the Market (Little Books. Big Profits). He defines ROC (Joel Greenblatt) % as EBIT divided by the total of Property, Plant and Equipment and net working capital. Spruce Biosciences's annualized ROC (Joel Greenblatt) % for the quarter that ended in Mar. 2026 was -7,354.16%.

The historical rank and industry rank for Spruce Biosciences's ROC (Joel Greenblatt) % or its related term are showing as below:

SPRB' s ROC (Joel Greenblatt) % Range Over the Past 10 Years
Min: -4986.19   Med: -3427.33   Max: -1629.45
Current: -4970.42

During the past 8 years, Spruce Biosciences's highest ROC (Joel Greenblatt) % was -1629.45%. The lowest was -4986.19%. And the median was -3427.33%.

SPRB's ROC (Joel Greenblatt) % is ranked worse than
84.82% of 1324 companies
in the Biotechnology industry
Industry Median: -297.06 vs SPRB: -4970.42

Spruce Biosciences's 5-Year average Growth Rate of ROC (Joel Greenblatt) % was -24.30% per year.


Spruce Biosciences  (NAS:SPRB) ROC (Joel Greenblatt) % Explanation

The way Joel Greenblatt defines Return on Capital is a more accurate measure of how efficiently the company generates returns onthe capital actually invested in the business. EBIT is used instead of net income because the tax and interest payment may be affected by factors other than the core business operation. Intangible assets are not included in the calculation because they don't need to be replaced.

Joel Greenblatt uses his definition of Return on Capital and Earnings Yield (Joel Greenblatt) % to rank companies.


Spruce Biosciences ROC (Joel Greenblatt) % Related Terms


Spruce Biosciences ROC (Joel Greenblatt) % Historical Data

* Premium members only.

The historical data trend for Spruce Biosciences's ROC (Joel Greenblatt) % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Spruce Biosciences ROC (Joel Greenblatt) % Chart

Spruce Biosciences Annual Data
Trend Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
ROC (Joel Greenblatt) %
Get a 7-Day Free Trial -2,564.00 -3,178.88 -3,675.78 -4,986.19 -4,859.50

Spruce Biosciences Quarterly Data
Jun21 Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
ROC (Joel Greenblatt) % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -6,214.09 -975.12 -4,261.64 -8,359.74 -7,354.16

SPRB vs TLSA, MIST, TNYA: ROC (Joel Greenblatt) % Comparison

For the Biotechnology subindustry, Spruce Biosciences's ROC (Joel Greenblatt) %, along with its competitors' market caps and ROC (Joel Greenblatt) % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Spruce Biosciences ROC (Joel Greenblatt) % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Spruce Biosciences's ROC (Joel Greenblatt) % distribution charts can be found below:

* The bar in red indicates where Spruce Biosciences's ROC (Joel Greenblatt) % falls into.


SPRB
40GF Score
Spruce Biosciences Inc SPRB
ROC (Joel Greenblatt) % is just one metric. See GF Score™, valuation, warning signs, and more.
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Spruce Biosciences ROC (Joel Greenblatt) % Calculation

Joel Greenblatt defined Return on Capital differently in his book The Little Book That Still Beats the Market (Little Books. Big Profits) . He defines Return on Capital as follows:

ROC (Joel Greenblatt) %=EBIT/Average of (Net fixed Assets + Net Working Capital)

EBIT stands for Earnings Before Interest and Taxes.

Fixed Assets are also known as non-current assets. They include the Property, Plant and Equipment that the firm needs in its operation.

GuruFocus calculates net working capital as: (Accounts Receivable + Total Inventories + Other Current Assets) - (Accounts Payable & Accrued Expense + Deferred Revenue + Other Current Liabilities). We're trying to account for OPERATING assets and liabilities (part of daily business) when calculating working capital. Cash and marketable securities are considered NON-OPERATING assets and are not included in calculation. We will also back out all interest bearing debt, short term debt and the portion of long term debt that is due in the current period from the current liabilities. This debt will be considered when computing cost of capital and it would be inappropriate to count it twice.

Working Capital(Q: Dec. 2025 )
=(Accounts Receivable + Total Inventories + Other Current Assets) - (Accounts Payable & Accrued Expense + Defer. Rev. + Other Current Liabilities)
=(0 + 0 + 3.206) - (7.995 + 0 + 1.774)
=-6.563

Working Capital(Q: Mar. 2026 )
=(Accounts Receivable + Total Inventories + Other Current Assets) - (Accounts Payable & Accrued Expense + Defer. Rev. + Other Current Liabilities)
=(0 + 0 + 0.952) - (9.818 + 0 + 0.64)
=-9.506

When net working capital is negative, 0 is used.

So ROC (Joel Greenblatt) % of Spruce Biosciences for the quarter that ended in Mar. 2026 can be restated as:

ROC (Joel Greenblatt) %(Q: Mar. 2026 )
=EBIT/Average of (Net fixed Assets + Net Working Capital)
=EBIT/Average of (Property, Plant and Equipment+Net Working Capital)
     Q: Dec. 2025  Q: Mar. 2026
=EBIT/( ( (Property, Plant and Equipment + Net Working Capital) + (Property, Plant and Equipment + Net Working Capital) )/ count )
=-46.368/( ( (0.666 + max(-6.563, 0)) + (0.595 + max(-9.506, 0)) )/ 2 )
=-46.368/( ( 0.666 + 0.595 )/ 2 )
=-46.368/0.6305
=-7,354.16 %

Note: The EBIT data used here is four times the quarterly (Mar. 2026) EBIT data.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

What does a ROC (Joel Greenblatt) % of -7,354.16% mean?
Spruce Biosciences (SPRB) has a ROC (Joel Greenblatt) % of -7,354.16% as of Mar. 2026. Joel Greenblatt's return on capital is the ratio of EBIT to average fixed assets and net working capital. View historical data on Spruce Biosciences and its competitors. According to the industry distribution chart, Spruce Biosciences ranks #1123 out of 1324 companies in the Biotechnology industry, placing it in the top 84.8%.
Is Spruce Biosciences' ROC (Joel Greenblatt) % too high?
Spruce Biosciences' current ROC (Joel Greenblatt) % is -7,354.16%. Based on the distribution chart, Spruce Biosciences ranks #1123 out of 1324 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Spruce Biosciences has a GF Score™ of 40/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Spruce Biosciences' ROC (Joel Greenblatt) % compare to TLSA and MIST?
According to the Biotechnology industry distribution chart, Spruce Biosciences ranks #1123 out of 1324 companies for ROC (Joel Greenblatt) %. This places Spruce Biosciences in the lower half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good ROC (Joel Greenblatt) % for a Biotechnology company?
A good ROC (Joel Greenblatt) % depends on the Biotechnology industry context. However, ROC (Joel Greenblatt) % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high ROC (Joel Greenblatt) % mean?
A high ROC (Joel Greenblatt) % can signal that a stock is expensive relative to its fundamentals. Joel Greenblatt's return on capital is the ratio of EBIT to average fixed assets and net working capital. View historical data on Spruce Biosciences and its competitors. Spruce Biosciences's current ROC (Joel Greenblatt) % is -7,354.16%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Spruce Biosciences stock overvalued right now?
Based on GuruFocus' analysis, Spruce Biosciences (SPRB) is currently considered Significantly Overvalued. The stock's GF Value™ is $4.08, compared to a current price of $52.51 — trading 1187% above its estimated fair value. The current ROC (Joel Greenblatt) % is -7,354.16%. Spruce Biosciences' overall GF Score™ is 40/100 with 1 warning sign to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is ROC (Joel Greenblatt) % calculated?
ROC (Joel Greenblatt) % is calculated from a company's financial statements. For Spruce Biosciences (SPRB), the current ROC (Joel Greenblatt) % is -7,354.16% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Spruce Biosciences (SPRB) Overvalued in 2026?

Based on GuruFocus' analysis, Spruce Biosciences stock appears to be overvalued. The current stock price of $52.51 is trading 1187% above its estimated GF Value™ of $4.08. GuruFocus considers Spruce Biosciences to be Significantly Overvalued.

Key valuation signals for SPRB:

  • ROC (Joel Greenblatt) %: -7,354.16%
  • GF Value™: $4.08 vs. price of $52.51 (1187% above fair value)
  • GF Score™: 40/100 with 1 warning sign

No single metric tells the full story. See the SPRB stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Spruce Biosciences Business Description

Address 611 Gateway Boulevard, Suite 740, South San Francisco, CA, USA, 94080
Spruce Biosciences Inc is a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for rare endocrine disorders with unmet medical needs. The company develops biologics and small-molecule product candidates aimed at addressing diseases with unmet medical needs and limited or no approved therapies. Its product candidate, TA-ERT for the treatment of Mucopolysaccharidosis Type IIIB (MPS IIIB), is a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase (rhNAGLU) intended as an enzyme replacement therapy for patients who lack rhNAGLU enzyme activity. TA-ERT is designed to restore rhNAGLU enzyme activity in the central nervous system following intracerebroventricular injection and promote clearance of heparan sulfate in the brain.
40GF Score

Get the complete analysis for SPRB

ROC (Joel Greenblatt) % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$52.51
Price
$4.08
GF Value