SPRB (Spruce Biosciences) Pre-Tax Income: $-51.35 Mil (TTM As of Jun. 2026)

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SPRB Spruce Biosciences Inc SPRB
42 GF Score
Price $60.46
GF Value $4.08
Valuation Significantly Overvalued
! 1 Warning Sign
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What is Spruce Biosciences Pre-Tax Income?

Spruce Biosciences SPRB -4.00% 42 Pre-Tax Income is $-51.35 Mil as of Jun. 2026. GuruFocus rates SPRB with a GF Score™ of 42/100 and a GF Value™ of $4.08 (Significantly Overvalued). The stock has 1 warning sign investors should review.

Pretax income is the income that a company earns before paying income taxes. Spruce Biosciences's pretax income for the three months ended in Jun. 2026 was $-16.23 Mil. Its pretax income for the trailing twelve months (TTM) ended in Jun. 2026 was $-51.35 Mil. Spruce Biosciences's pretax margin was %.

During the past 8 years, Spruce Biosciences's highest Pretax Margin was -474.96%. The lowest was -1079.94%. And the median was -777.45%.


Spruce Biosciences  (NAS:SPRB) Pre-Tax Income Explanation

Spruce Biosciences's Pretax Margin for the quarter that ended in Jun. 2026 is calculated as

Pretax Margin=Pretax Income/Revenue
=-16.229/0
=%

During the past 8 years, Spruce Biosciences's highest Pretax Margin was -474.96%. The lowest was -1079.94%. And the median was -777.45%.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.


Spruce Biosciences Pre-Tax Income Related Terms


Spruce Biosciences Pre-Tax Income Historical Data

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The historical data trend for Spruce Biosciences's Pre-Tax Income can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Spruce Biosciences Pre-Tax Income Chart

Spruce Biosciences Annual Data
Trend Dec18 Dec19 Dec20 Dec21 Dec22 Dec23 Dec24 Dec25
Pre-Tax Income
Get a 7-Day Free Trial -42.29 -46.18 -47.92 -53.04 -38.97

Spruce Biosciences Quarterly Data
Sep21 Dec21 Mar22 Jun22 Sep22 Dec22 Mar23 Jun23 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26 Jun26
Pre-Tax Income Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only Premium Member Only -2.07 -8.21 -14.65 -12.27 -16.23

SPRB vs VXRT, VTVT, ENGN: Pre-Tax Income Comparison

For the Biotechnology subindustry, Spruce Biosciences's Pre-Tax Income, along with its competitors' market caps and Pre-Tax Income data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Spruce Biosciences Pre-Tax Income vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Spruce Biosciences's Pre-Tax Income distribution charts can be found below:

* The bar in red indicates where Spruce Biosciences's Pre-Tax Income falls into.


SPRB
42GF Score
Spruce Biosciences Inc SPRB
Pre-Tax Income is just one metric. See GF Score™, valuation, warning signs, and more.
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Spruce Biosciences Pre-Tax Income Calculation

This is the income that a company earns before paying income taxes.

Spruce Biosciences's Pretax Income for the fiscal year that ended in Dec. 2025 is calculated as

Pretax Income=Operating Income+Non Operating Income+Interest Expense+Interest Income+Other
=-36.513+-3.5+-0.09+1.137+0
=-38.97

Spruce Biosciences's Pretax Income for the quarter that ended in Jun. 2026 is calculated as

Pretax Income=Operating Income+Non Operating Income+Interest Expense+Interest Income+Other
=-16.512+0.615+-1.097+0.765+3.5527136788005E-15
=-16.23

Pre-Tax Income for the trailing twelve months (TTM) ended in Jun. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-51.35 Mil.

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about Pre-Tax Income →
What does a Pre-Tax Income of $-51.35 Mil mean?
Spruce Biosciences (SPRB) has a Pre-Tax Income of $-51.35 Mil as of Jun. 2026. Pre-Tax Income is the total earnings before taxes but after all operating and interest expenses. View historical data on Spruce Biosciences and its competitors.
Is Spruce Biosciences' Pre-Tax Income too high?
Spruce Biosciences' current Pre-Tax Income is $-51.35 Mil. Overall, Spruce Biosciences has a GF Score™ of 42/100 and is considered Significantly Overvalued, reflecting its overall financial health beyond just this single metric.
How does Spruce Biosciences' Pre-Tax Income compare to VXRT and VTVT?
Spruce Biosciences' Pre-Tax Income of $-51.35 Mil can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Pre-Tax Income for a Biotechnology company?
A good Pre-Tax Income depends on the Biotechnology industry context. However, Pre-Tax Income should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Pre-Tax Income mean?
A high Pre-Tax Income can signal that a stock is expensive relative to its fundamentals. Pre-Tax Income is the total earnings before taxes but after all operating and interest expenses. View historical data on Spruce Biosciences and its competitors. Spruce Biosciences's current Pre-Tax Income is $-51.35 Mil. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Spruce Biosciences stock overvalued right now?
Based on GuruFocus' analysis, Spruce Biosciences (SPRB) is currently considered Significantly Overvalued. The stock's GF Value™ is $4.08, compared to a current price of $60.46 — trading 1381.9% above its estimated fair value. The current Pre-Tax Income is $-51.35 Mil. Spruce Biosciences' overall GF Score™ is 42/100 with 1 warning sign to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Pre-Tax Income calculated?
Pre-Tax Income is calculated from a company's financial statements. For Spruce Biosciences (SPRB), the current Pre-Tax Income is $-51.35 Mil as of Jun. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Is Spruce Biosciences (SPRB) Overvalued in 2026?

Based on GuruFocus' analysis, Spruce Biosciences stock appears to be overvalued. The current stock price of $60.46 is trading 1381.9% above its estimated GF Value™ of $4.08. GuruFocus considers Spruce Biosciences to be Significantly Overvalued.

Key valuation signals for SPRB:

  • Pre-Tax Income: $-51.35 Mil
  • GF Value™: $4.08 vs. price of $60.46 (1381.9% above fair value)
  • GF Score™: 42/100 with 1 warning sign

No single metric tells the full story. See the SPRB stock analysis page for a complete view including 30-year financials, guru trades, and insider activity.


Spruce Biosciences Business Description

Address 611 Gateway Boulevard, Suite 740, South San Francisco, CA, USA, 94080
Spruce Biosciences Inc is a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for rare endocrine disorders with unmet medical needs. The company develops biologics and small-molecule product candidates aimed at addressing diseases with unmet medical needs and limited or no approved therapies. Its product candidate, TA-ERT for the treatment of Mucopolysaccharidosis Type IIIB (MPS IIIB), is a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase (rhNAGLU) intended as an enzyme replacement therapy for patients who lack rhNAGLU enzyme activity. TA-ERT is designed to restore rhNAGLU enzyme activity in the central nervous system following intracerebroventricular injection and promote clearance of heparan sulfate in the brain.
42GF Score

Get the complete analysis for SPRB

Pre-Tax Income is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$60.46
Price
$4.08
GF Value