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SepternaSEPN +1.98%12 Debt-to-Equity is 0.06 as of Jun. 2026, which is at its 10-year median of 0.06. GuruFocus rates SEPN with a GF Score™ of 12/100. The stock has 4 warning signs investors should review. Among 954 Biotechnology companies, Septerna ranks better than 68.34% on this metric.
A high debt to equity ratio generally means that a company has been aggressive in financing its growth with debt. This can result in volatile earnings as a result of the additional interest expense.
The historical rank and industry rank for Septerna's Debt-to-Equity or its related term are showing as below:
SEPN'
s Debt-to-Equity Range Over the Past 10 Years
Min: -0.33 Med: 0.06 Max: 0.07
Current: 0.06
During the past 4 years, the highest Debt-to-Equity Ratio of Septerna was 0.07. The lowest was -0.33. And the median was 0.06.
SEPN's Debt-to-Equity is ranked better than 68.34% of 954
companies
in the Biotechnology industry
Industry Median: 0.16
vs SEPN: 0.06
Because a company can increase its ROE % by having more financial leverage, it is important to watch the leverage ratio when investing in high ROE % companies.
Septerna Debt-to-Equity Related Terms
Septerna Debt-to-Equity Historical Data
* Premium members only.
The historical data trend for Septerna's Debt-to-Equity can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
SEPN vs NTLA, AVBP, VIR: Debt-to-Equity Comparison
For the Biotechnology subindustry, Septerna's Debt-to-Equity, along with its competitors' market caps and Debt-to-Equity data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Septerna Debt-to-Equity vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Septerna's Debt-to-Equity distribution charts can be found below:
* The bar in red indicates where Septerna's Debt-to-Equity falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Septerna (SEPN) has a Debt-to-Equity of 0.06 as of Jun. 2026. Debt-to-Equity ratio represents the ratio of total debt to total company equity. View historical data on Septerna and its competitors. This is near median its historical median of 0.06. According to the industry distribution chart, Septerna ranks #302 out of 954 companies in the Biotechnology industry, placing it in the top 31.7%.
Is Septerna's Debt-to-Equity too high?
Septerna's current Debt-to-Equity of 0.06 is near median its 10-year median of 0.06. The Biotechnology industry median Debt-to-Equity is 0.16. Septerna's value of 0.06 is 62.5% below this industry median. Based on the distribution chart, Septerna ranks #302 out of 954 companies in the Biotechnology industry, which is above the industry midpoint. Overall, Septerna has a GF Score™ of 12/100, reflecting its overall financial health beyond just this single metric.
How does Septerna's Debt-to-Equity compare to NTLA and AVBP?
According to the Biotechnology industry distribution chart, Septerna ranks #302 out of 954 companies for Debt-to-Equity. This puts Septerna in the upper half of its industry. The industry median Debt-to-Equity is 0.16. Septerna's value of 0.06 is 62.5% below this benchmark. While the company's 10-year median is 0.06 vs. the industry median of 0.16, Septerna has consistently been below the industry average. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Debt-to-Equity for a Biotechnology company?
The median Debt-to-Equity among Biotechnology companies is 0.16, based on 954 companies in the industry. Companies in the top quartile (top 25%) have a Debt-to-Equity significantly above this median, while those in the bottom quartile fall well below. However, Debt-to-Equity should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Septerna's current Debt-to-Equity of 0.06 is 62.5% below the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Debt-to-Equity mean?
A high Debt-to-Equity can signal that a stock is expensive relative to its fundamentals. Debt-to-Equity ratio represents the ratio of total debt to total company equity. View historical data on Septerna and its competitors. For the Biotechnology industry, the median Debt-to-Equity is 0.16 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Septerna's current Debt-to-Equity is 0.06, which is near median its own 10-year median of 0.06. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Septerna stock overvalued right now?
Septerna (SEPN) has a current Debt-to-Equity of 0.06. The current Debt-to-Equity is 0.06, which is near median its 10-year median of 0.06 and 62.5% below the Biotechnology industry median of 0.16. Septerna's overall GF Score™ is 12/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Debt-to-Equity calculated?
Debt-to-Equity is calculated from a company's financial statements. For Septerna (SEPN), the current Debt-to-Equity is 0.06 as of Jun. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Septerna Inc is a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) oral small molecule drug discovery powered by a proprietary Native Complex Platform. Its industrial-scale platform aims to unlock the full potential of GPCR therapies. The group discovery and development of a pipeline of product candidates focused initially on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic disease. Its pipeline includes SEP-786 (PTH1R), SEP-631 (MRGPRX2), TSHR, GLP-1R, GIPR, and GCGR.
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