SEPN (Septerna) Tariff Resilience Score: 5/10 (As of Aug. 08, 2026)

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SEPN Septerna Inc SEPN
12 GF Score
Price $38.83
! 4 Warning Signs
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What is Septerna Tariff Resilience Score?

Septerna SEPN -1.77% 12 Tariff Resilience Score is 5 as of Aug. 08, 2026. GuruFocus rates SEPN with a GF Score™ of 12/100. The stock has 4 warning signs investors should review. Among 1,367 Biotechnology companies, Septerna ranks better than 62.47% on this metric.

Septerna has the Tariff Resilience Score of 5, which implies that the company might have Average Resilient.

Septerna has U.S.-based operations with some international sales. Moderate import/export balance. Previous tariffs have had limited impact. Mitigation through alternative suppliers is possible but not fully developed.

Tariff Resilience Score is a ranking system developed by GuruFocus to measure a company's exposure to international trade tariffs, rated on a scale from 0 to 10. It takes into account key factors such as global supply chain dependencies, manufacturing locations versus sales markets, import / export balance and percentage of revenue, and more.

The company's exposure to international trade tariffs based on these criteria:

1. Global supply chain dependencies
2. Manufacturing locations versus sales markets
3. Import/export balance and percentage of revenue
4. Historical impact from previous tariff changes
5. Available mitigation strategies (alternative suppliers, pricing power)
6. Industry-specific tariff exemptions or vulnerabilities

Based on the research, GuruFocus believes Septerna might have Average Resilient.

Septerna  (NAS:SEPN) Tariff Resilience Score Explanation

The Tariff Resilience Score ranges from 0 to 10, with 10 as the most resilient. GuruFocus divided Moat Score into following 3 categories:

Tariff Resilience Score Resilience Level
7 - 10Highly Resilient
4 - 6Average Resilient
0 - 3Highly Vulnerable

Septerna Tariff Resilience Score Related Terms

SEPN vs NTLA, AVBP, VIR: Tariff Resilience Score Comparison

For the Biotechnology subindustry, Septerna's Tariff Resilience Score, along with its competitors' market caps and Tariff Resilience Score data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.

Septerna Tariff Resilience Score vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Septerna's Tariff Resilience Score distribution charts can be found below:

* The bar in red indicates where Septerna's Tariff Resilience Score falls into.


SEPN
12GF Score
Septerna Inc SEPN
Tariff Resilience Score is just one metric. See GF Score™, valuation, warning signs, and more.
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What does a Tariff Resilience Score of 5 mean?
Septerna (SEPN) has a Tariff Resilience Score of 5 as of Aug. 08, 2026. Tariff Score is a ranking system developed by GuruFocus to measure a company's exposure to international trade tariffs, rated on a scale from 0 to 10. It takes into account key factors such as global supply chain dependencies, manufacturing locations versus sales markets, import / export balance and percentage of revenue, and more. According to the industry distribution chart, Septerna ranks #513 out of 1367 companies in the Biotechnology industry, placing it in the top 37.5%.
Is Septerna's Tariff Resilience Score too high?
Septerna's current Tariff Resilience Score is 5. The Biotechnology industry median Tariff Resilience Score is 4.00. Septerna's value of 5 is 25% above this industry median. Based on the distribution chart, Septerna ranks #513 out of 1367 companies in the Biotechnology industry, which is above the industry midpoint. Overall, Septerna has a GF Score™ of 12/100, reflecting its overall financial health beyond just this single metric.
How does Septerna's Tariff Resilience Score compare to NTLA and AVBP?
According to the Biotechnology industry distribution chart, Septerna ranks #513 out of 1367 companies for Tariff Resilience Score. This puts Septerna in the upper half of its industry. The industry median Tariff Resilience Score is 4.00. Septerna's value of 5 is 25% above this benchmark. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Tariff Resilience Score for a Biotechnology company?
The median Tariff Resilience Score among Biotechnology companies is 4.00, based on 1,367 companies in the industry. Companies in the top quartile (top 25%) have a Tariff Resilience Score significantly above this median, while those in the bottom quartile fall well below. However, Tariff Resilience Score should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Septerna's current Tariff Resilience Score of 5 is 25% above the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Tariff Resilience Score mean?
A high Tariff Resilience Score can signal that a stock is expensive relative to its fundamentals. Tariff Score is a ranking system developed by GuruFocus to measure a company's exposure to international trade tariffs, rated on a scale from 0 to 10. It takes into account key factors such as global supply chain dependencies, manufacturing locations versus sales markets, import / export balance and percentage of revenue, and more. For the Biotechnology industry, the median Tariff Resilience Score is 4.00 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Septerna's current Tariff Resilience Score is 5. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Septerna stock overvalued right now?
Septerna (SEPN) has a current Tariff Resilience Score of 5. The current Tariff Resilience Score is 5 and 25% above the Biotechnology industry median of 4.00. Septerna's overall GF Score™ is 12/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Tariff Resilience Score calculated?
Tariff Resilience Score is calculated from a company's financial statements. For Septerna (SEPN), the current Tariff Resilience Score is 5 as of Aug. 08, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Septerna Business Description

Address 250 East Grand Avenue, South San Francisco, CA, USA, 94080
Septerna Inc is a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) oral small molecule drug discovery powered by a proprietary Native Complex Platform. Its industrial-scale platform aims to unlock the full potential of GPCR therapies. The group discovery and development of a pipeline of product candidates focused initially on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic disease. Its pipeline includes SEP-786 (PTH1R), SEP-631 (MRGPRX2), TSHR, GLP-1R, GIPR, and GCGR.
12GF Score

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Tariff Resilience Score is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

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