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SepternaSEPN -1.29%12 EV-to-EBIT is -30.10 as of Aug. 18, 2026. GuruFocus rates SEPN with a GF Score™ of 12/100. The stock has 4 warning signs investors should review. Among 370 Biotechnology companies, Septerna ranks worse than 270270% on this metric.
EV-to-EBIT is calculated as Enterprise Value divided by its EBIT. As of today, Septerna's Enterprise Value is $1,686.74 Mil.
Septerna's EBIT for the trailing twelve months (TTM) ended in Jun. 2026 was $-56.05 Mil. Therefore, Septerna's EV-to-EBIT for today is -30.10.
The historical rank and industry rank for Septerna's EV-to-EBIT or its related term are showing as below:
SEPN'
s EV-to-EBIT Range Over the Past 10 Years
Min: -30.85 Med: -8.47 Max: 0.84
Current: -30.1
During the past 4 years, the highest EV-to-EBIT of Septerna was 0.84. The lowest was -30.85. And the median was -8.47.
SEPN's EV-to-EBIT is ranked worse than 100% of 370
companies
in the Biotechnology industry
Industry Median: 16.115
vs SEPN: -30.10
This is a more accurate valuation of companies' operation because it considers the debt and cash on its balance sheet, and non-operating items such as interest payment, tax, and one-time items are not included in the Operating Income.
Septerna's Enterprise Value for the quarter that ended in Jun. 2026 was $1,179.61 Mil.
Septerna's EBIT for the trailing twelve months (TTM) ended in Jun. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-56.05 Mil.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Septerna EV-to-EBIT Related Terms
Septerna EV-to-EBIT Historical Data
* Premium members only.
The historical data trend for Septerna's EV-to-EBIT can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
For the Biotechnology subindustry, Septerna's EV-to-EBIT, along with its competitors' market caps and EV-to-EBIT data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Septerna EV-to-EBIT vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Septerna's EV-to-EBIT distribution charts can be found below:
* The bar in red indicates where Septerna's EV-to-EBIT falls into.
Septerna's current Enterprise Value is $1,686.74 Mil.
Septerna's EBIT for the trailing twelve months (TTM) ended in Jun. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-56.05 Mil.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Septerna (SEPN) has a EV-to-EBIT of -30.10 as of Aug. 18, 2026. EV to EBIT ratio is the inverse of Joel Greenblatt's earnings yield definition. View historical data on Septerna and its competitors. According to the industry distribution chart, Septerna ranks #999999 out of 370 companies in the Biotechnology industry.
Is Septerna's EV-to-EBIT too high?
Septerna's current EV-to-EBIT is -30.10. Based on the distribution chart, Septerna ranks #999999 out of 370 companies in the Biotechnology industry, which is in the bottom quartile relative to peers. Overall, Septerna has a GF Score™ of 12/100, reflecting its overall financial health beyond just this single metric.
How does Septerna's EV-to-EBIT compare to NTLA and AVBP?
According to the Biotechnology industry distribution chart, Septerna ranks #999999 out of 370 companies for EV-to-EBIT. This places Septerna in the lower half of its industry. The industry median EV-to-EBIT is 16.12. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good EV-to-EBIT for a Biotechnology company?
The median EV-to-EBIT among Biotechnology companies is 16.12, based on 370 companies in the industry. Companies in the top quartile (top 25%) have a EV-to-EBIT significantly above this median, while those in the bottom quartile fall well below. However, EV-to-EBIT should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high EV-to-EBIT mean?
A high EV-to-EBIT can signal that a stock is expensive relative to its fundamentals. EV to EBIT ratio is the inverse of Joel Greenblatt's earnings yield definition. View historical data on Septerna and its competitors. For the Biotechnology industry, the median EV-to-EBIT is 16.12 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Septerna's current EV-to-EBIT is -30.10. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Septerna stock overvalued right now?
Septerna (SEPN) has a current EV-to-EBIT of -30.10. The current EV-to-EBIT is -30.10. Septerna's overall GF Score™ is 12/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is EV-to-EBIT calculated?
EV-to-EBIT is calculated from a company's financial statements. For Septerna (SEPN), the current EV-to-EBIT is -30.10 as of Aug. 18, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Septerna Inc is a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) oral small molecule drug discovery powered by a proprietary Native Complex Platform. Its industrial-scale platform aims to unlock the full potential of GPCR therapies. The group discovery and development of a pipeline of product candidates focused initially on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic disease. Its pipeline includes SEP-786 (PTH1R), SEP-631 (MRGPRX2), TSHR, GLP-1R, GIPR, and GCGR.
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