SEPN (Septerna) Tax Rate %: -4.06% (As of Mar. 2026)

Author: Vera Yuan Vera Yuan
Vera Yuan
Vera Yuan
Director of Data and Quant Analytics at GuruFocus
Focused on building reliable datasets, financial models, and research tools for value-minded investors. Committed to turning complex data into practical guidance for value-investing and long-term wealth.
Reviewed by: Charlie Tian Charlie Tian
Charlie Tian
Charlie Tian
Founder & CEO of GuruFocus
Dr. Charlie Tian is the founder and CEO of GuruFocus.com, a leading global investment research platform established in 2004. With a Ph.D. in physics, Dr. Tian transitioned from science to finance, applying a data-driven, disciplined approach to value investing.

SEPN Septerna Inc SEPN
12 GF Score
Price $38.83
! 4 Warning Signs
View Full Analysis

What is Septerna Tax Rate %?

Septerna SEPN -1.77% 12 Tax Rate % is -4.06% as of Mar. 2026. GuruFocus rates SEPN with a GF Score™ of 12/100. The stock has 4 warning signs investors should review.

Tax Rate % is calculated as Tax Expense divided by its Pre-Tax Income. Septerna's Tax Expense for the three months ended in Mar. 2026 was $0.34 Mil. Septerna's Pre-Tax Income for the three months ended in Mar. 2026 was $-8.30 Mil. Therefore, Septerna's Tax Rate % for the quarter that ended in Mar. 2026 was -4.06%.

Septerna Tax Rate % Related Terms

Septerna Tax Rate % Historical Data

* Premium members only.

The historical data trend for Septerna's Tax Rate % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Septerna Tax Rate % Chart

Septerna Annual Data
Trend Dec22 Dec23 Dec24 Dec25
Tax Rate %
0.00 14.19 0.69 -0.02

Septerna Quarterly Data
Dec22 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
Tax Rate % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only 0.00 0.00 0.00 -0.11 -4.06
SEPN
12GF Score
Septerna Inc SEPN
Tax Rate % is just one metric. See GF Score™, valuation, warning signs, and more.
View Full Analysis

Septerna Tax Rate % Calculation

Tax Rate % is the ratio of tax expense divided by pretax income, usually presented in percent.

Septerna's Tax Rate % for the fiscal year that ended in Dec. 2025 is calculated as

Tax Rate %=Tax Expense (A: Dec. 2025 )/Pre-Tax Income (A: Dec. 2025 )
=0.012/-48.867
=-0.02 %

Septerna's Tax Rate % for the quarter that ended in Mar. 2026 is calculated as

Tax Rate %=Tax Expense (Q: Mar. 2026 )/Pre-Tax Income (Q: Mar. 2026 )
=0.337/-8.3
=-4.06 %

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about Tax Rate % →
What does a Tax Rate % of -4.06% mean?
Septerna (SEPN) has a Tax Rate % of -4.06% as of Mar. 2026.
Is Septerna's Tax Rate % too high?
Septerna's current Tax Rate % is -4.06%. Overall, Septerna has a GF Score™ of 12/100, reflecting its overall financial health beyond just this single metric.
How does Septerna's Tax Rate % compare to NTLA and AVBP?
Septerna's Tax Rate % of -4.06% can be compared against companies in the Biotechnology industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Tax Rate % for a Biotechnology company?
A good Tax Rate % depends on the Biotechnology industry context. However, Tax Rate % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Tax Rate % mean?
A high Tax Rate % can signal that a stock is expensive relative to its fundamentals. Septerna's current Tax Rate % is -4.06%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Septerna stock overvalued right now?
Septerna (SEPN) has a current Tax Rate % of -4.06%. The current Tax Rate % is -4.06%. Septerna's overall GF Score™ is 12/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Tax Rate % calculated?
Tax Rate % is calculated from a company's financial statements. For Septerna (SEPN), the current Tax Rate % is -4.06% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Septerna Business Description

Address 250 East Grand Avenue, South San Francisco, CA, USA, 94080
Septerna Inc is a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) oral small molecule drug discovery powered by a proprietary Native Complex Platform. Its industrial-scale platform aims to unlock the full potential of GPCR therapies. The group discovery and development of a pipeline of product candidates focused initially on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic disease. Its pipeline includes SEP-786 (PTH1R), SEP-631 (MRGPRX2), TSHR, GLP-1R, GIPR, and GCGR.
12GF Score

Get the complete analysis for SEPN

Tax Rate % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

$38.83
Price