SEPN (Septerna) OCF Yield %: 6.16 (As of Aug. 08, 2026)

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SEPN Septerna Inc SEPN
12 GF Score
Price $38.83
! 4 Warning Signs
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What is Septerna OCF Yield %?

Septerna SEPN -1.77% 12 OCF Yield % is 6.16 as of Aug. 08, 2026. GuruFocus rates SEPN with a GF Score™ of 12/100. The stock has 4 warning signs investors should review. Among 1,410 Biotechnology companies, Septerna ranks better than 92.34% on this metric.

OCF Yield % is calculated as Cash Flow from Operations divided by Market Capitalization. It is a financial solvency ratio that compares the operating cash flow a company is expected to earn against its market value.

As of today, Septerna's Trailing 12-Month Cash Flow from Operations is $107.90 Mil, and Market Cap is $1,750.28 Mil. Therefore, Septerna's OCF Yield % for today is 6.16%.

The historical rank and industry rank for Septerna's OCF Yield % or its related term are showing as below:

SEPN' s OCF Yield % Range Over the Past 10 Years
Min: -30.78   Med: -5.16   Max: 12.35
Current: 6.16


During the past 4 years, the highest OCF Yield % of Septerna was 12.35%. The lowest was -30.78%. And the median was -5.16%.

SEPN's OCF Yield % is ranked better than
92.34% of 1410 companies
in the Biotechnology industry
Industry Median: -8.485 vs SEPN: 6.16

Septerna's OCF Margin % for the quarter that ended in Mar. 2026 was %.


Septerna OCF Yield % Explanation

Similar to Earnings Yield %, OCF Yield % is financial solvency ratio. A lower ratio suggests a less attractive investment, indicating that investors might not receive substantial returns in proportion to their investment. Conversely, a high operating cash flow yield signals that a company generates sufficient cash to comfortably meet its debts, obligations, and dividend payments, making it a promising investment choice.


Septerna OCF Yield % Related Terms


Septerna OCF Yield % Historical Data

* Premium members only.

The historical data trend for Septerna's OCF Yield % can be seen below:

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Septerna OCF Yield % Chart

Septerna Annual Data
Trend Dec22 Dec23 Dec24 Dec25
OCF Yield %
0.00 0.00 -6.63 8.82

Septerna Quarterly Data
Dec22 Sep23 Dec23 Mar24 Jun24 Sep24 Dec24 Mar25 Jun25 Sep25 Dec25 Mar26
OCF Yield % Get a 7-Day Free Trial Premium Member Only Premium Member Only Premium Member Only Premium Member Only -36.28 -17.23 80.42 -4.80 -9.50

SEPN vs NTLA, AVBP, VIR: OCF Yield % Comparison

For the Biotechnology subindustry, Septerna's OCF Yield %, along with its competitors' market caps and OCF Yield % data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.


Septerna OCF Yield % vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Septerna's OCF Yield % distribution charts can be found below:

* The bar in red indicates where Septerna's OCF Yield % falls into.


SEPN
12GF Score
Septerna Inc SEPN
OCF Yield % is just one metric. See GF Score™, valuation, warning signs, and more.
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Septerna OCF Yield % Calculation

OCF Yield % is a financial solvency ratio that compares the operating cash flow a company is expected to earn against its market value.

Septerna's OCF Yield % for the fiscal year that ended in Dec. 2025 is calculated as

OCF Yield %=Cash Flow from Operations / Market Cap
=110.189 / 1249.19128
=8.82%

Septerna's annualized OCF Yield % for the quarter that ended in Mar. 2026 is calculated as

OCF Yield %=Cash Flow from Operations * Annualized Factor / Market Cap
=-25.633 * 4 / 1079.35551
=-9.50%

* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD.
* For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.

Frequently Asked Questions Learn more about OCF Yield % →
What does a OCF Yield % of 6.16 mean?
Septerna (SEPN) has a OCF Yield % of 6.16 as of Aug. 08, 2026. OCF Yield is calculated as Cash Flow from Operations divided by Market Capitalization. View historical data on Septerna and its competitors. According to the industry distribution chart, Septerna ranks #108 out of 1410 companies in the Biotechnology industry, placing it in the top 7.7%.
Is Septerna's OCF Yield % too high?
Septerna's current OCF Yield % is 6.16. Based on the distribution chart, Septerna ranks #108 out of 1410 companies in the Biotechnology industry, which is in the top quartile — a strong position relative to peers. Overall, Septerna has a GF Score™ of 12/100, reflecting its overall financial health beyond just this single metric.
How does Septerna's OCF Yield % compare to NTLA and AVBP?
According to the Biotechnology industry distribution chart, Septerna ranks #108 out of 1410 companies for OCF Yield %. This places Septerna in the top 8% of its industry — outperforming the majority of peers. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good OCF Yield % for a Biotechnology company?
A good OCF Yield % depends on the Biotechnology industry context. However, OCF Yield % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high OCF Yield % mean?
A high OCF Yield % can signal that a stock is expensive relative to its fundamentals. OCF Yield is calculated as Cash Flow from Operations divided by Market Capitalization. View historical data on Septerna and its competitors. Septerna's current OCF Yield % is 6.16. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Septerna stock overvalued right now?
Septerna (SEPN) has a current OCF Yield % of 6.16. The current OCF Yield % is 6.16. Septerna's overall GF Score™ is 12/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is OCF Yield % calculated?
OCF Yield % is calculated from a company's financial statements. For Septerna (SEPN), the current OCF Yield % is 6.16 as of Aug. 08, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Septerna Business Description

Address 250 East Grand Avenue, South San Francisco, CA, USA, 94080
Septerna Inc is a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) oral small molecule drug discovery powered by a proprietary Native Complex Platform. Its industrial-scale platform aims to unlock the full potential of GPCR therapies. The group discovery and development of a pipeline of product candidates focused initially on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic disease. Its pipeline includes SEP-786 (PTH1R), SEP-631 (MRGPRX2), TSHR, GLP-1R, GIPR, and GCGR.
12GF Score

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OCF Yield % is just one metric. See GF Value™, 30-year financials, guru trades, warning signs, and more.

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