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SepternaSEPN -1.77%12 Market Cap is $1,750.28 Mil as of Aug. 08, 2026. GuruFocus rates SEPN with a GF Score™ of 12/100. The stock has 4 warning signs investors should review. Among 1,423 Biotechnology companies, Septerna ranks better than 86.37% on this metric.
Market cap is the total market value to buy the whole company. It is equal to the share price times the number of Shares Outstanding (EOP). Septerna's share price for the quarter that ended in Mar. 2026 was $24.03. Septerna's Shares Outstanding (EOP) for the quarter that ended in Mar. 2026 was 44.92 Mil. Therefore, Septerna's market cap for the quarter that ended in Mar. 2026 was $1,079.36 Mil.
Septerna's quarterly market cap
increased
from Sep. 2025 ($839.66 Mil) to Dec. 2025 ($1,249.19 Mil) but then
declined
from Dec. 2025 ($1,249.19 Mil) to Mar. 2026 ($1,079.36 Mil).
Septerna's annual market cap
increased
from Dec. 2023 ($0.00 Mil) to Dec. 2024 ($1,017.29 Mil) and
increased
from Dec. 2024 ($1,017.29 Mil) to Dec. 2025 ($1,249.19 Mil).
Enterprise Value is the theoretical takeover price. It is more comprehensive than market capitalization (market cap), which only includes common equity. Enterprise Value is calculated as the market cap plus debt and minority interest and preferred shares, minus total cash and cash equivalents. Septerna's Enterprise Value for Today is $1,425.97 Mil.
Market cap is not the real price you pay for a company. If you buy the company and become its owner, you become the owner of the cash the company has, and you also assume the companys debt. The real price you pay is the Enterprise Value.
Warren Buffett uses the ratio of total market cap of all public traded companies over GDP to measure if the market is expensive. As of April 2012, the US total market cap is about $14.7 trillion, while the US GDP is about $15 trillion. The market was modestly overvalued.
Septerna Market Cap Related Terms
Septerna Market Cap Historical Data
* Premium members only.
The historical data trend for Septerna's Market Cap can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
For the Biotechnology subindustry, Septerna's Market Cap, along with its competitors' market caps and Market Cap data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Septerna Market Cap vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Septerna's Market Cap distribution charts can be found below:
* The bar in red indicates where Septerna's Market Cap falls into.
Market cap is the short version of market capitalization. It is the total market value to buy the whole company. It is equal to the share price times the number of shares outstanding.
Septerna's Market Cap for the fiscal year that ended in Dec. 2025 is calculated as
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
Septerna (SEPN) has a Market Cap of $1,750.28 Mil as of Aug. 08, 2026. Market cap equals the total value of a company's shares: price times shares outstanding. View historical data on Septerna and its competitors. According to the industry distribution chart, Septerna ranks #194 out of 1423 companies in the Biotechnology industry, placing it in the top 13.6%.
Is Septerna's Market Cap too high?
Septerna's current Market Cap is $1,750.28 Mil. The Biotechnology industry median Market Cap is 116.70. Septerna's value of $1,750.28 Mil is 1399.8% above this industry median. Based on the distribution chart, Septerna ranks #194 out of 1423 companies in the Biotechnology industry, which is in the top quartile — a strong position relative to peers. Overall, Septerna has a GF Score™ of 12/100, reflecting its overall financial health beyond just this single metric.
How does Septerna's Market Cap compare to NTLA and AVBP?
According to the Biotechnology industry distribution chart, Septerna ranks #194 out of 1423 companies for Market Cap. This places Septerna in the top 14% of its industry — outperforming the majority of peers. The industry median Market Cap is 116.70. Septerna's value of $1,750.28 Mil is 1399.8% above this benchmark. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Market Cap for a Biotechnology company?
The median Market Cap among Biotechnology companies is 116.70, based on 1,423 companies in the industry. Companies in the top quartile (top 25%) have a Market Cap significantly above this median, while those in the bottom quartile fall well below. However, Market Cap should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Septerna's current Market Cap of $1,750.28 Mil is 1399.8% above the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Market Cap mean?
A high Market Cap can signal that a stock is expensive relative to its fundamentals. Market cap equals the total value of a company's shares: price times shares outstanding. View historical data on Septerna and its competitors. For the Biotechnology industry, the median Market Cap is 116.70 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Septerna's current Market Cap is $1,750.28 Mil. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Septerna stock overvalued right now?
Septerna (SEPN) has a current Market Cap of $1,750.28 Mil. The current Market Cap is $1,750.28 Mil and 1399.8% above the Biotechnology industry median of 116.70. Septerna's overall GF Score™ is 12/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Market Cap calculated?
Market Cap is calculated from a company's financial statements. For Septerna (SEPN), the current Market Cap is $1,750.28 Mil as of Aug. 08, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Septerna Inc is a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) oral small molecule drug discovery powered by a proprietary Native Complex Platform. Its industrial-scale platform aims to unlock the full potential of GPCR therapies. The group discovery and development of a pipeline of product candidates focused initially on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic disease. Its pipeline includes SEP-786 (PTH1R), SEP-631 (MRGPRX2), TSHR, GLP-1R, GIPR, and GCGR.
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