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SepternaSEPN -1.77%12 Return-on-Tangible-Equity is -9.09% as of Mar. 2026. GuruFocus rates SEPN with a GF Score™ of 12/100. The stock has 4 warning signs investors should review. Among 1,201 Biotechnology companies, Septerna ranks better than 70.69% on this metric.
Return-on-Tangible-Equity is calculated as Net Income divided by its average total shareholder tangible equity. Total shareholder tangible equity equals to Total Stockholders Equity minus Intangible Assets. Septerna's annualized net income for the quarter that ended in Mar. 2026 was $-34.55 Mil. Septerna's average shareholder tangible equity for the quarter that ended in Mar. 2026 was $380.19 Mil. Therefore, Septerna's annualized Return-on-Tangible-Equity for the quarter that ended in Mar. 2026 was -9.09%.
The historical rank and industry rank for Septerna's Return-on-Tangible-Equity or its related term are showing as below:
SEPN'
s Return-on-Tangible-Equity Range Over the Past 10 Years
Min: -37.62 Med: -24.91 Max: -9.35
Current: -9.35
During the past 4 years, Septerna's highest Return-on-Tangible-Equity was -9.35%. The lowest was -37.62%. And the median was -24.91%.
SEPN's Return-on-Tangible-Equity is ranked better than 70.69% of 1201
companies
in the Biotechnology industry
Industry Median: -42.68
vs SEPN: -9.35
Return-on-Tangible-Equity measures the rate of return on the ownership interest (shareholder's tangible equity) of the common stock owners. It measures a firm's efficiency at generating profits from every unit of shareholders' tangible equity (shareholders equity minus intangibles). Return-on-Tangible-Equity shows how well a company uses investment funds to generate earnings growth. Return-on-Tangible-Equitys between 15% and 20% are considered desirable.
Be Aware
Net Income is used.
Because a company can increase its Return-on-Tangible-Equity by having more financial leverage, it is important to watch the leverage ratio when investing in high Return-on-Tangible-Equity companies. Like Return-on-Tangible-Asset, Return-on-Tangible-Equity is calculated with only 12 months data. Fluctuations in company's earnings or business cycles can affect the ratio drastically. It is important to look at the ratio from a long term perspective.
Asset light businesses require very few assets to generate very high earnings. Their Return-on-Tangible-Equitys can be extremely high.
Septerna Return-on-Tangible-Equity Related Terms
Septerna Return-on-Tangible-Equity Historical Data
* Premium members only.
The historical data trend for Septerna's Return-on-Tangible-Equity can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
SEPN vs NTLA, AVBP, VIR: Return-on-Tangible-Equity Comparison
For the Biotechnology subindustry, Septerna's Return-on-Tangible-Equity, along with its competitors' market caps and Return-on-Tangible-Equity data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Septerna Return-on-Tangible-Equity vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Septerna's Return-on-Tangible-Equity distribution charts can be found below:
* The bar in red indicates where Septerna's Return-on-Tangible-Equity falls into.
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
In the calculation of annual Return-on-Tangible-Equity, the net income of the last fiscal year and the average total shareholder tangible equity over the fiscal year are used. In calculating the quarterly data,
the net income data used here is four times the quarterly (Mar. 2026) net income data.
Return-on-Tangible-Equity is displayed in the 10-year financial page.
What does a Return-on-Tangible-Equity of -9.09% mean?
Septerna (SEPN) has a Return-on-Tangible-Equity of -9.09% as of Mar. 2026. Return on tangible equity is the ratio of current-period net income to average two-period tangible equity. View historical data on Septerna and its competitors. According to the industry distribution chart, Septerna ranks #352 out of 1201 companies in the Biotechnology industry, placing it in the top 29.3%.
Is Septerna's Return-on-Tangible-Equity too high?
Septerna's current Return-on-Tangible-Equity is -9.09%. Based on the distribution chart, Septerna ranks #352 out of 1201 companies in the Biotechnology industry, which is above the industry midpoint. Overall, Septerna has a GF Score™ of 12/100, reflecting its overall financial health beyond just this single metric.
How does Septerna's Return-on-Tangible-Equity compare to NTLA and AVBP?
According to the Biotechnology industry distribution chart, Septerna ranks #352 out of 1201 companies for Return-on-Tangible-Equity. This puts Septerna in the upper half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Return-on-Tangible-Equity for a Biotechnology company?
A good Return-on-Tangible-Equity depends on the Biotechnology industry context. However, Return-on-Tangible-Equity should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Return-on-Tangible-Equity mean?
A high Return-on-Tangible-Equity can signal that a stock is expensive relative to its fundamentals. Return on tangible equity is the ratio of current-period net income to average two-period tangible equity. View historical data on Septerna and its competitors. Septerna's current Return-on-Tangible-Equity is -9.09%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Septerna stock overvalued right now?
Septerna (SEPN) has a current Return-on-Tangible-Equity of -9.09%. The current Return-on-Tangible-Equity is -9.09%. Septerna's overall GF Score™ is 12/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Return-on-Tangible-Equity calculated?
Return-on-Tangible-Equity is calculated from a company's financial statements. For Septerna (SEPN), the current Return-on-Tangible-Equity is -9.09% as of Mar. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Septerna Inc is a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) oral small molecule drug discovery powered by a proprietary Native Complex Platform. Its industrial-scale platform aims to unlock the full potential of GPCR therapies. The group discovery and development of a pipeline of product candidates focused initially on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic disease. Its pipeline includes SEP-786 (PTH1R), SEP-631 (MRGPRX2), TSHR, GLP-1R, GIPR, and GCGR.
12GF Score
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