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SepternaSEPN -0.86%12 Earnings Yield (Joel Greenblatt) % is -4.75% as of Jun. 2026. GuruFocus rates SEPN with a GF Score™ of 12/100. The stock has 2 warning signs investors should review. Among 1,341 Biotechnology companies, Septerna ranks better than 64.28% on this metric.
Septerna's Enterprise Value for the quarter that ended in Jun. 2026 was $1,179.61 Mil.
Septerna's EBIT for the trailing twelve months (TTM) ended in Jun. 2026 was $-56.05 Mil. Septerna's Earnings Yield (Joel Greenblatt) for the quarter that ended in Jun. 2026 was -4.75%.
The historical rank and industry rank for Septerna's Earnings Yield (Joel Greenblatt) % or its related term are showing as below:
SEPN'
s Earnings Yield (Joel Greenblatt) % Range Over the Past 10 Years
Min: -516.38 Med: -9.79 Max: 535.45
Current: -4.02
During the past 4 years, the highest Earnings Yield (Joel Greenblatt) of Septerna was 535.45%. The lowest was -516.38%. And the median was -9.79%.
SEPN's Earnings Yield (Joel Greenblatt) % is ranked better than 64.28% of 1341
companies
in the Biotechnology industry
Industry Median: -10.09
vs SEPN: -4.02
Joel Greenblatt's definition of earnings yield has the same problems the regular earnings yield does. It does not consider the growth of the company. It only looks at one-year's business operation. For cyclical companies, the earnings yield is usually highest at the peak of the business cycle. But these earnings are rarely sustainable.
A better indicator of the attractiveness of an investment which takes growth into account is the Forward Rate of Return (Yacktman) %. Septerna's Forward Rate of Return (Yacktman) % for the quarter that ended in Jun. 2026 was 0.00%. The Forward Rate of Return uses the normalized Free Cash Flow of the past five years, and considers growth. The forward rate of return can be thought of as the return that investors buying the stock today can expect from it in the future.
Joel Greenblatt defines the earnings yield using the above equation because it more accurately reflects the company's profitability relative to its stock price. Items like interest payment and tax etc. are not directly related to the company's operational profitability.
Enterprise Value instead of market cap (share price) is used in the calculation because it is the real price stock and bond investors together pay for the company.
Be Aware
Joel Greenblatt's definition of earnings yield has the same problems the regular earnings yield does. It does not consider the growth of the company. It only looks at one-year's business operation. For cyclical companies, the earnings yield is usually highest at the peak of the business cycle. But these earnings are rarely sustainable.
Septerna Earnings Yield (Joel Greenblatt) % Related Terms
Septerna Earnings Yield (Joel Greenblatt) % Historical Data
* Premium members only.
The historical data trend for Septerna's Earnings Yield (Joel Greenblatt) % can be seen below:
* For Operating Data section: All numbers are indicated by the unit behind each term and all currency related amount are in USD. * For other sections: All numbers are in millions except for per share data, ratio, and percentage. All currency related amount are indicated in the company's associated stock exchange currency.
For the Biotechnology subindustry, Septerna's Earnings Yield (Joel Greenblatt) %, along with its competitors' market caps and Earnings Yield (Joel Greenblatt) % data, can be viewed below:
* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.
Septerna Earnings Yield (Joel Greenblatt) % vs Biotechnology Industry
For the Biotechnology industry and Healthcare sector, Septerna's Earnings Yield (Joel Greenblatt) % distribution charts can be found below:
* The bar in red indicates where Septerna's Earnings Yield (Joel Greenblatt) % falls into.
In his book, The Little That Beat the Market, hedge fund manager Joel Greenblatt defines Earnings Yield as operating income divided by enterprise value.
Septernas Earnings Yield (Joel Greenblatt) for the fiscal year that ended in Dec. 2025 is calculated as
Septerna's EBIT for the trailing twelve months (TTM) ended in Jun. 2026 adds up the quarterly data reported by the company within the most recent 12 months, which was $-56.05 Mil.
What does a Earnings Yield (Joel Greenblatt) % of -4.75% mean?
Septerna (SEPN) has a Earnings Yield (Joel Greenblatt) % of -4.75% as of Jun. 2026. Joel Greenblatt's earnings yield equals the ratio of earnings before interest and taxes to enterprise value. View historical data on Septerna and its competitors. According to the industry distribution chart, Septerna ranks #479 out of 1341 companies in the Biotechnology industry, placing it in the top 35.7%.
Is Septerna's Earnings Yield (Joel Greenblatt) % too high?
Septerna's current Earnings Yield (Joel Greenblatt) % is -4.75%. Based on the distribution chart, Septerna ranks #479 out of 1341 companies in the Biotechnology industry, which is above the industry midpoint. Overall, Septerna has a GF Score™ of 12/100, reflecting its overall financial health beyond just this single metric.
How does Septerna's Earnings Yield (Joel Greenblatt) % compare to INBX and NTLA?
According to the Biotechnology industry distribution chart, Septerna ranks #479 out of 1341 companies for Earnings Yield (Joel Greenblatt) %. This puts Septerna in the upper half of its industry. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Earnings Yield (Joel Greenblatt) % for a Biotechnology company?
A good Earnings Yield (Joel Greenblatt) % depends on the Biotechnology industry context. However, Earnings Yield (Joel Greenblatt) % should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Earnings Yield (Joel Greenblatt) % mean?
A high Earnings Yield (Joel Greenblatt) % can signal that a stock is expensive relative to its fundamentals. Joel Greenblatt's earnings yield equals the ratio of earnings before interest and taxes to enterprise value. View historical data on Septerna and its competitors. Septerna's current Earnings Yield (Joel Greenblatt) % is -4.75%. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Septerna stock overvalued right now?
Septerna (SEPN) has a current Earnings Yield (Joel Greenblatt) % of -4.75%. The current Earnings Yield (Joel Greenblatt) % is -4.75%. Septerna's overall GF Score™ is 12/100 with 2 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Earnings Yield (Joel Greenblatt) % calculated?
Earnings Yield (Joel Greenblatt) % is calculated from a company's financial statements. For Septerna (SEPN), the current Earnings Yield (Joel Greenblatt) % is -4.75% as of Jun. 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.
Septerna Inc is a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) oral small molecule drug discovery powered by a proprietary Native Complex Platform. Its industrial-scale platform aims to unlock the full potential of GPCR therapies. The group discovery and development of a pipeline of product candidates focused initially on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic disease. Its pipeline includes SEP-786 (PTH1R), SEP-631 (MRGPRX2), TSHR, GLP-1R, GIPR, and GCGR.
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