SEPN (Septerna) Moat Score: 3/10 (As of Aug. 08, 2026)

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SEPN Septerna Inc SEPN
12 GF Score
Price $38.83
! 4 Warning Signs
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What is Septerna Moat Score?

Septerna SEPN -1.77% 12 Moat Score is 3 as of Aug. 08, 2026. GuruFocus rates SEPN with a GF Score™ of 12/100. The stock has 4 warning signs investors should review. Among 1,393 Biotechnology companies, Septerna ranks better than 75.59% on this metric.

Septerna has the Moat Score of 3, which implies that the company might have No Moat - Very weak/transient advantages.

Septerna has No Moat: Septerna Inc has limited market presence and lacks significant intellectual property or customer loyalty. Its competitive advantages are weak and transient, resulting in a very weak moat.

Moat Score is a ranking system developed by GuruFocus to assess a company's ability to sustain a competitive advantage, rated on a scale from 0 to 10. It takes into account key factors such as market leadership, cost advantages, network effects, customer switching costs, and more.

The company's Moat Score is based on these criteria:

1. Market leadership and sustainable market share
2. Network effects and significant customer switching costs
3. Valuable intellectual property and patents
4. Strong brand strength and deep customer loyalty
5. Durable cost advantages (e.g., economies of scale, proprietary technology)
6. Significant regulatory barriers and exclusive licenses
7. Superior distribution network
8. Strong and sustainable pricing power
9. Consistent and impactful innovation and R&D capabilities

Based on the research, GuruFocus believes Septerna might have No Moat - Very weak/transient advantages.

Septerna  (NAS:SEPN) Moat Score Explanation

The Moat Score ranges from 0 to 10, with 10 as the highest. GuruFocus divided Moat Score into following 8 categories:

Moat Score Moat Level
10Wide Moat - Exceptionally dominant and durable wide moat
8 - 9Wide Moat - Clear and robust wide moat
7Wide Moat - Entry-level wide moat, clearly possessing durable advantages
6Narrow Moat - Strong narrow moat, clearly distinguishable but not wide
5Narrow Moat - Solid narrow moat
4Narrow Moat - Discernible but modest moat
1 - 3No Moat - Very weak/transient advantages
0No Moat - No discernible moat

Septerna Moat Score Related Terms

SEPN vs NTLA, AVBP, VIR: Moat Score Comparison

For the Biotechnology subindustry, Septerna's Moat Score, along with its competitors' market caps and Moat Score data, can be viewed below:

* Competitive companies are chosen from companies within the same industry, with headquarter located in same country, with closest market capitalization; x-axis shows the market cap, and y-axis shows the term value; the bigger the dot, the larger the market cap. Note that "N/A" values will not show up in the chart.

Septerna Moat Score vs Biotechnology Industry

For the Biotechnology industry and Healthcare sector, Septerna's Moat Score distribution charts can be found below:

* The bar in red indicates where Septerna's Moat Score falls into.


SEPN
12GF Score
Septerna Inc SEPN
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Frequently Asked Questions Learn more about Moat Score →
What does a Moat Score of 3 mean?
Septerna (SEPN) has a Moat Score of 3 as of Aug. 08, 2026. Moat Score is a ranking system developed by GuruFocus to assess a company's ability to sustain a competitive advantage, rated on a scale from 0 to 10. It takes into account key factors such as market leadership, cost advantages, network effects, customer switching costs, and more. According to the industry distribution chart, Septerna ranks #340 out of 1393 companies in the Biotechnology industry, placing it in the top 24.4%.
Is Septerna's Moat Score too high?
Septerna's current Moat Score is 3. The Biotechnology industry median Moat Score is 2.00. Septerna's value of 3 is 50% above this industry median. Based on the distribution chart, Septerna ranks #340 out of 1393 companies in the Biotechnology industry, which is in the top quartile — a strong position relative to peers. Overall, Septerna has a GF Score™ of 12/100, reflecting its overall financial health beyond just this single metric.
How does Septerna's Moat Score compare to NTLA and AVBP?
According to the Biotechnology industry distribution chart, Septerna ranks #340 out of 1393 companies for Moat Score. This places Septerna in the top 24% of its industry — outperforming the majority of peers. The industry median Moat Score is 2.00. Septerna's value of 3 is 50% above this benchmark. See the competitive comparison table and distribution chart on this page for a detailed peer-by-peer breakdown.
What is a good Moat Score for a Biotechnology company?
The median Moat Score among Biotechnology companies is 2.00, based on 1,393 companies in the industry. Companies in the top quartile (top 25%) have a Moat Score significantly above this median, while those in the bottom quartile fall well below. However, Moat Score should not be evaluated in isolation — investors should consider it alongside profitability, growth, and financial strength metrics. Septerna's current Moat Score of 3 is 50% above the industry median. Use the industry distribution chart on this page to see where any company falls relative to its peers.
What does a high Moat Score mean?
A high Moat Score can signal that a stock is expensive relative to its fundamentals. Moat Score is a ranking system developed by GuruFocus to assess a company's ability to sustain a competitive advantage, rated on a scale from 0 to 10. It takes into account key factors such as market leadership, cost advantages, network effects, customer switching costs, and more. For the Biotechnology industry, the median Moat Score is 2.00 — values significantly above this may indicate overvaluation, while values below may suggest a bargain or underlying issues. Septerna's current Moat Score is 3. However, context matters — high-growth companies often justify higher valuations. Always evaluate alongside other metrics like GF Score™ and GF Value™.
Is Septerna stock overvalued right now?
Septerna (SEPN) has a current Moat Score of 3. The current Moat Score is 3 and 50% above the Biotechnology industry median of 2.00. Septerna's overall GF Score™ is 12/100 with 4 warning signs to review. Investors should evaluate multiple metrics — including profitability, growth, and financial strength — before making a decision.
How is Moat Score calculated?
Moat Score is calculated from a company's financial statements. For Septerna (SEPN), the current Moat Score is 3 as of Aug. 08, 2026. GuruFocus calculates this using data sourced from SEC filings and annual reports. See the calculation section and 30-year financial data on this page for the full breakdown.

Septerna Business Description

Address 250 East Grand Avenue, South San Francisco, CA, USA, 94080
Septerna Inc is a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) oral small molecule drug discovery powered by a proprietary Native Complex Platform. Its industrial-scale platform aims to unlock the full potential of GPCR therapies. The group discovery and development of a pipeline of product candidates focused initially on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic disease. Its pipeline includes SEP-786 (PTH1R), SEP-631 (MRGPRX2), TSHR, GLP-1R, GIPR, and GCGR.
12GF Score

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